既往血吸虫病感染人群大肠癌发病风险研究  

Study on the Risk of Colorectal Cancer in the Population with Past Schistosomiasis Infection

作　　者：朱美英[1] 张桃莉 吴巧敏[1] 蔡滨欣[1] 柳胜生[1] 计凤妹[1] 

机构地区：[1]上海市松江区疾病预防控制中心,上海201620 [2]上海市松江区岳阳街道社区卫生服务中心,上海201600

出　　处：《中国肿瘤》2015年第11期900-904,共5页China Cancer

基　　金：上海市松江区医学合作课题(2011LX-12)

摘　　要：[目的]分析既往血吸虫病疫区感染人群大肠癌发病风险,为制定大肠癌预防和控制策略提供依据。[方法]比较上海市松江区既往血吸虫病疫区与非疫区大肠癌发病情况;并对2012年220 175名筛查对象的筛查资料进行非条件Logistic回归分析。[结果 ]2002～2009年松江区大肠癌发病呈上升趋势;松江区既往血吸虫病疫区（车墩、洞泾、中山、佘山、泗泾、九亭、新桥）的大肠癌发病率高于其他非疫区（岳阳、泖港、小昆山、叶榭、方松、石湖荡、新浜、永丰）;2005～2009年松江区大肠癌发病率高于与上海市其他非血吸虫病疫区区县。非条件性Logistic回归分析表明血吸虫感染与大肠癌发病相关（OR=6.048,95%CI：5.249～6.971,P〈0.001）。[结论 ]既往血吸虫病疫区感染人群大肠癌发病风险增高。[Purpose] To investigate the risk of colorectal cancer in the population with past Schistosomiasis infection,and to provide evidences for the prevention and treatment of colorectal cancer.[Methods] The standardized incidence of colorectal cancer between the past Schistosomiasis epidemic and un-epidemic areas in Songjiang district,Shanghai compared and analyzed,and the data of 220 175 screening objects in 2012 was analyzed by Logistic regression. [Results] The incidence of colorectal cancer was increasing from 2002 to 2009 in Songjiang district. The incidence of colorectal cancer in past Schistosomiasis epidemic areas（Chedun,Dongjing,Zhongshan,Sheshan,Sijing,Jiuting,Xinqiao was higher than that in un-epidemic areas（Yueyang,Maogang,Xiaokunshan,Yexie,Fangsong,Shihudang,Xinbang,Yongfeng in Songjiang district. The incidence of colorectal cancer in Songjiang district was higher than that in past Schistosomiasis un-epidemic districts of Shanghai. The Logistic regression showed that the occurrence of colorectal cancer was related to the Schistosomiasis infection（OR=6.048,95%CI：5.249～6.971,P〈0.001）. [Conclusion]The risk of colorectal cancer increased in the population with past Schistosomiasis infection.

关 键 词：既往血吸虫病感染 大肠癌 危险因素 

分 类 号：R735.3[医药卫生—肿瘤]