帕金森病患者血浆α-synuclein、Aβ及tau蛋白变化特点  

Characteristics of α-synuclein, Amyloid-β and Tau Proteins in the Plasma of Patients with Parkinson's Disease

作　　者：陈东万[1] 王叶冉[1] 曹红元[1] 严家川[1] 周华东[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所神经内科,重庆400042

出　　处：《现代生物医学进展》2015年第33期6472-6475,共4页Progress in Modern Biomedicine

基　　金：中国博士后基金项目(2012M521861;2013T60955);重庆博士后基金项目(Xm201342)

摘　　要：目的:探索帕金森病(Parkinson's disease,PD)患者血浆中α-突触核蛋白、Aβ及tau蛋白变化情况。方法:募集2014年4月至2015年4月来我院就诊的PD患者62例,正常对照人群59例,采集两组人群的基本临床信息,测定血浆中α-突触核蛋白、Aβ40、Aβ42、p T181-tau蛋白、p T231-tau蛋白和总tau蛋白浓度,比较两组之间的差异,同时进行相关性分析。结果:PD患者血浆α-突触核蛋白和p T181-tau蛋白浓度显著高于对照组(P值分别为0.001,0.019),而两组间Aβ40、Aβ42、p T231-tau蛋白和总tau蛋白浓度无明显差异(P>0.05)。相关性分析提示PD患者血浆α-突触核蛋白和p T181-tau蛋白浓度与患者年龄、性别、教育程度、病程、高血压、糖尿病、Hoehn/Yahr分级及Schwab&England评分无相关性(P>0.05)。结论:虽然PD患者血浆α-突触核蛋白和p T181-tau蛋白高于正常对照组,但尚不适宜作为PD的生物标志物。Objective： To investigate the changes in the levels ofα-synuclein, amyloid-β （Aβ） and tau proteins in the plasma of patients with Parkinson＇s disease. Methods： The study was carded out on patients with Parkinson＇s disease （PD） and normal controls （NC）. Participants with PD （n=59）, NC （n=62） were consecutively recruited during a 1-year period from April 2014 to April 2015 from Daping Hospital, and the clinical data were collected. The concentrations of α-synuclein, amyloid-β and tau proteins in the plasma of PD and NC groups were measured and compared between two groups. Moreover, correlation analysis was also performed. Results： The concentrations of α-synuclein and tau phosphorylated at threonine 181 （pT 181-tau） in the PD group were significantly higher than those in the NC group （P=0.001, 0.019, respectively）. There were no significance differences in the concentrations of Aβ40, Aβ42, pT231-tau and total-tau between two groups （P〉0.05）. Correlation analysis indicated that et-synuclein and pT181-tau did not correlated with age, gender, education, disease duration, hypertension, diabetes, Hoehn and Yahr stage and Schwab ＆ England score （P〉0.05）. Conclusions： Although the plasma levels of α-synuclein and pT181-tau were found to be increased in PD patients, they seem not be capable of being biomarkers for PD.

关 键 词：帕金森病 Α-突触核蛋白 Β淀粉样肽 TAU蛋白 

分 类 号：R742.5[医药卫生—神经病学与精神病学]