腹腔热灌注联合肿瘤细胞减灭术治疗晚期子宫内膜癌的疗效  

Clinical Efficacy of Cytoreductive Surgery Combined with Intraperitoneal Hyperthermic Chemoperfusion Treatment for Advanced Endometrial Carcinoma

作　　者：杨元娟[1,2] 何凌[1] 熊晶[1] 王丽琼[2] 朱付凡[1] 

机构地区：[1]中南大学湘雅二医院,湖南长沙410011 [2]香港大学深圳医院妇产科,广东深圳518000

出　　处：《现代生物医学进展》2015年第31期6050-6052,共3页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81201730)

摘　　要：目的:探讨IHCP+CDS治疗晚期子宫内膜癌的临床疗效和安全性。方法:选取治疗确诊为晚期子宫内膜癌的患者84例,随机分为观察组和对照组。观察组采用IHCP+CDS方案化疗,对照组采用常规灌注+肿瘤细胞减灭术方案化疗。比较两组的手术时间、临床疗效、复发率、生存时间和不良反应等。结果:观察组手术时间和术中腹水量比对照组少,两组差异明显(P<0.05);观察组总有效率和24个月生存率比对照组高,而复发率比对照组低(P<0.05);观察组恶心、麻木发生率较对照组低(P<0.05);而白细胞降低、血小板降低和盆腔感染方面相互比较,无显著差异(P>0.05)。结论:IHCP+CDS能有效改善晚期子宫内膜癌患者术前和术后对化疗的耐受性;提高患者的生存率和临床治疗效果。Objective： To explore the clinical effect and safety of cytoreductive surgery（CDS） combined with intraperitoneal hyperthermic chemoperfusion（IHCP） treatment on advanced endometrial carcinoma. Methods： The diagnosed 84 cases of advanced endometrial carcinoma patients were divided randomly into observing group and control group. Patients in observing group were treated with IHCP＋CDS, and those in control group were treated with ordinary chemotherapy＋ CDS. Compare the operation time, clinical curative effect, recurrence rate, survival time and adverse reaction between two groups. Results： The operation time was shorter and intraoperative ascites was less in observing group than in control group, and the difference was statistical（P〈0.05）. The total effective rate and24-month survival rate was better in observing group than in control group（P〈0.05）. The observing group also had a lower reoccurrence rate than the control group（P〈0.05）. The incidences of nausea and numbness were lower in observing group than in control group（P〈0.05）; but there was no significant difference between two groups in leukopenia, thrombocytopenia and pelvic infection. Conclusion：IHCP＋CDS could improve the general situation of preoperative advanced endometrial cancer, preoperative and postoperative chemotherapy tolerance, and the survival and clinical patient outcomes.

关 键 词：腹腔热灌注 肿瘤细胞减灭术 子宫内膜癌 

分 类 号：R737.33[医药卫生—肿瘤]