肺鳞癌、腺癌组织中miRNA-210表达对预后影响的初步研究  

Prognostic Impact of mi RNA-210 for Squamous Cell Carcinoma and Adenocarcinoma of the Lung

作　　者：陆莎[1] 祖超[2] 陈召[2] 王艳[2] 冯征[2] 卢强[2] 张天翼[2] 李小飞[2] 

机构地区：[1]西安市中心医院重症医学科,陕西西安710003 [2]第四军医大学唐都医院胸腔外科,陕西西安710038

出　　处：《现代生物医学进展》2015年第31期6095-6100,共6页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81172224)

摘　　要：目的:探讨肺鳞癌腺癌组织中mi RNA-210表达水平对预后的影响。方法:选取我院2004年至2007年接受手术治疗的肺鳞癌腺癌患者80例,采用定量RT-PCR测定的方法 mi RNA-210在肺癌组织中的表达,并分析其与患者临床病理特点及组织类型之间的关系。结果:定量RT-PCR测定结果显示,mi RNA-210与肺鳞癌腺癌患者的无病生存期和总生存期负相关(DFS,P=0.001;OS,P=0.004)。mi RNA-210与腺癌患者淋巴结转移(P=0.018)、晚期疾病(P=0.003)及较差的预后(P=0.002)显著相关。多因素Cox分析显示mi RNA-210是腺癌患者无病生存期的独立预后因子(P<0.001)。结论:肺腺癌病人肿瘤组织重mi RNA-210可能为预后的生物标志物。Objective： To investigate the prognostic value of Micro RNA-210（mi RNA-210） expression in patients with squamous cell carcinoma and adenocarcinoma of the lung. Methods： We examined the mi RNA-210 expression of samples of 80 patients, who underwent surgicalresection at our hospital from 2004 to 2007, by using quantitative RT-PCR. The relationship between mi RNA-210 expression and clinicopathological factors as well as histological subtype was statistically analyzed. Results： mi RNA-210 expression showed an inverse correlation with disease-free and overall survival in patients with squamous cell carcinoma and adenocarcinoma of the lung by using quantitative RT-PCR（DFS, P=0.001; OS, P=0.004）. Significant correlations were found between mi RNA-210 expression and lymph node metastasis（P=0.018）, late disease stages（P=0.003）, and poor prognosis in patients with adenocarcinoma（P=0.002）. Multivariate Cox analysis indicated that mi RNA-210 expression was an independent prognostic factor for disease-free survival in patients with adenocarcinoma（P〈0.001）. Conclusions： We showed that mi RNA-210 may be a prognostic biomarker for patients with squamous cell carcinoma and adenocarcinoma of the lung, especially for those with lung adenocarcinoma.

关 键 词：mi RNA-210 肺鳞癌腺癌 预后因素 

分 类 号：R734.2[医药卫生—肿瘤]