治疗前18F—FDGPET—CT最大标准摄取值在软组织肉瘤中的预后价值  

Prognostic value of maximum standard uptake of pretreatment 18F-FDG PET-CT in newly diagnosed soft tissue sarcoma

作　　者：丁重阳[1] 杨文平[1] 孙晋[1] 李洋洋[1] 杨伟[1] 李天女[1] 

机构地区：[1]南京医科大学第一附属医院核医学科,210029

出　　处：《肿瘤研究与临床》2015年第10期673-676,共4页Cancer Research and Clinic

基　　金：南京市科技计划（201303038）

摘　　要：目的探讨软组织肉瘤（STS）患者治疗前18F-FDGPET-CT最大标准摄取值（SUVmax）的预后价值。方法回顾性分析34例经病理确诊的STS患者资料，所有患者于治疗前行18F-FDGPET-CT检查，采用Mann—Whitney非参数检验及Spearman相关性检验评价SUVmax与预后因子的关系。采用Kaplan—Meier法进行生存分析，COX模型进行多因素分析。结果34例STS中位SUVmax为10.3（1．5。28．2），肿瘤最大直径为6．7cm（1．8—17．2cm），两者呈正相关（r=0．389，P=0．028）。SUVmax与病理学分级、美国癌症联合委员会（AJCC）分期及远处转移均有相关性（均P〈0．05）。单因素分析结果显示，远处转移、病理学分级、AJCC分期及SUVmax与STS患者的生存相关（均P〈0．05），而年龄、性别、发病部位及肿块大小与生存均无相关性（均P〉0．05）。多因素分析显示，远处转移及SUVmax是影响患者生存的独立危险因素（均P〈0．05）。结论STS患者治疗前。18F-FDGPET-CT的SUVmax与患者的预后因子间具有较好的相关性，能够预测患者的预后。Objective To determine the prognostic value of maximum standard uptake （SUVmax） of pretreatment 18F-FDG PET-CT in patients with newly diagnosed soft tissue sarcomas （STS）. Methods The clinical data of 34 patients with STS undergoing18F-FDG PET-CT before treatment were analyzed retrospectively. The relationship between SUVmax of PET-CT and prognostic factors was evaluated by Mann- Whitney＂ s non-paraetric test and Spearman＂ s rank correlation test. The prognostic factors were analyzed by univariate and multivariate analysis. Results Among 34 patients, the median SUVmax was 10.3 （1.5-28.2）, and the median maximum diameter was 6.7 cm （1.8-17.2 cm） with positively association between them （r = 0.389, P = 0.028）. SUVmax was also associated with pathological grade, AJCC staging and distant metastasis, respectively （all P 〈 0.05）. In univariate analysis, distant metastasis, pathological grade, AJCC staging, and SUVmax were found to be the prognostic factors （all P 〈 0.05）. Multivariate analysis results indicated that only the SUVmax and distant metastasis were the independent unfavorable prognostic factors （both P 〈 0.05）. Conclusions TheSUVmax of pretreatment 18F-FDG PET-CT is well correlated with prognostic factors, and it can predict the prognosis of patients with STS.

关 键 词：软组织肉瘤 体层摄影术 发射型计算机 体层摄影术 x线计算机 预后 

分 类 号：R738.6[医药卫生—肿瘤]