食管癌放疗患者386例贫血状况及其对预后的影响  

The incidence of anemia in 386 patients with esophageal carcinoma undergoing radiotherapy and its effect on prognosis

作　　者：倪亚非[1] 任超峰[1] 夏吉凯[1] 

机构地区：[1]四川省内江市第一人民医院肿瘤科,641000

出　　处：《肿瘤研究与临床》2015年第10期690-693,共4页Cancer Research and Clinic

摘　　要：目的了解食管癌患者贫血状况并探讨放疗前贫血对食管癌患者预后的影响。方法回顾性分析386例食管癌患者放疗前后血红蛋白（Hb）水平，比较放疗前贫血组与正常组放疗后1、3、5年生存率，分析贫血对患者预后的影响以及与其他临床因素的相关性。结果386例患者中，放疗前贫血患者179例（46．3％），血红蛋白（Hh）49～169g／L（中位值116g／L）；放疗后贫血患者286例（74．2％），Hb45—152g／L（中位值98g／L）。放疗前后食管癌患者贫血发生率比较，差异有统计学意义（χ2=61．915，P〈0．001）。食管癌患者肿瘤分期越晚、Karnofsky评分越低、体质量指数（BMI）越低、治疗前体质量下降越多，贫血发生率越高（P〈0．05）。放疗前贫血组中位生存期为42个月，正常组为52个月，两组差异有统计学意义（χ2=5．002，P=0．025）。放疗前贫血组中未接受治疗者占87．7％。结论食管癌放疗患者放疗前后的贫血发生情况均较严重，放疗前贫血可导致食管癌患者生存率降低，应及时纠正患者贫血以提高生存率。Objective To investigate the incidence of anemia among patients with esophageal carcinoma undergoing radiotherapy, and to explore its influence on prognosis. Methods The data of 386 patients with esophageal carcinoma undergoing radiotherapy were collected retrospectively. The survival rates of the 1st, 3rd, 5th year were compared between the anemia group and non-anemia group. Analysis was carried on the impact factors of amenia on the prognosis and other clinical factors. Results The incidence of anemia before radiotherapy was 46.3 % （179/386）, and the level of hemoglobin was 116 g/L （49-169 g/L）. The incidence of anemia after radiotherapy was 74.2 % （286/386）, and the level of hemoglobin was 98 g/L （45-152 g/L）, The incidences of anemia between before and after radiotherapy were statistically different （χ2 = 61.915, P 〈 0.001）. The incidence of anemia before radiotherapy was associated with stage, Karnofsky score, BMI and the weight loss before treatment （P 〈 0.05）. The median survival time of the anemia group was 42 months, while that of the non-anemia group was 52 months, and the difference was statistically significant （χ2= 5.002, P = 0.025）. There were 87.7 % of anemia patients got no treatment. Conclusions The prevalences of anemia before and after radiotherapy are high, and anemia before radiotherapy can decrease the survival rate in esophageal carcinoma patients. Methods should be taken to improve the haemoglobin level in order to increase the survival rate,

关 键 词：食管肿瘤 放射疗法 贫血 预后 

分 类 号：R735.1[医药卫生—肿瘤]