选择性剪接机制及其在白血病诊疗中的应用  

Mechanism of alternative splicing and its application in diagnosis and treatment of leukemia

作　　者：刘静[1] 张静[1] 黄波[1] 王小中[1] 

机构地区：[1]南昌大学第二附属医院检验科,330006

出　　处：《中华检验医学杂志》2015年第11期730-732,共3页Chinese Journal of Laboratory Medicine

基　　金：国家自然科学基金（81271912,81560033）;江西省教育厅课题（GJJ13041）

摘　　要：选择性剪接是指真核细胞选择性地对前信使RNA（pre—mRNA）剪接位点的组合剪接加工，形成不同的成熟信使RNA（mRNA），从而使一个基因产生若干有独特结构和功能的蛋白质异构体的过程。其过程受多种顺式作用元件和反式作用因子的调控。近年发现异常选择性剪接在多种不同类型白血病患者体内普遍存在，与白血病的发生、发展及化疗抵抗等密切相关，在白血病诊断及治疗中有广阔的应用前景。Alternative splicing is a process refering a pre-mRNA transforms to different mature mRNAs by different splicing sites combination, and then the mRNAs translate to various proteins. This process is regulated by a variety of cis acting elements and trans acting factors. Recent studies have shown that aberrant alternative splicing is prevalent in leukemia patients, and is closely associated with leukemic occurrence, development and chemotherapy resistance. This shows us that aberrant alternative splicing may be helpful to leukemia diagnosis and treatment.

关 键 词：白血病 选择性剪接 生物学标记 

分 类 号：R733.7[医药卫生—肿瘤]