脑微出血与腔隙性脑梗死患者卒中后抑郁的相关性分析  

Analysis on the correlation of cerebral microbleeds and post-stroke depression in lacunar stroke

作　　者：牛晓波[1] 缑元冲[1] 郭旭亮[1] 

机构地区：[1]河南省安阳市灯塔医院神经内科,安阳455000

出　　处：《临床医学》2015年第10期41-43,共3页Clinical Medicine

摘　　要：目的探讨脑微出血(CMB)与腔隙性脑梗死(LI)患者卒中后抑郁的相关性。方法选择腔隙性脑梗死患者216例,进行老年抑郁量表(GDS)评测,≥5分为存在抑郁,分为抑郁组和无抑郁组。记录两组CMB总数量及脑叶CMB、深部CMB、幕下CMB及左右半球CMB数量,分析两组CMB数量与部位、人口学资料、临床资料及影像学资料的关系。结果两组在脑叶CMB及左半球CMB、女性、美国国立卫生研究院卒中量表(NIHSS)评分、脑白质病变(WML)、深部LI及左半球LI等方面比较差异有统计学意义(P<0.05)。多因素分析提示脑叶CMB是卒中后抑郁(PSD)的独立危险因素(OR=5.843,P=0.040)。结论脑叶CMB及左半球CMB为PSD危险因素,其他危险因素包括女性、较严重的神经功能缺损、脑白质病变、LI特别是深部及左半球LI。Objective To investigate the correlation of cerebral microbleeds（ CMB） and post-stroke depression in lacunar stroke. Methods A total of 216 patients with acute lacunar stroke were selected. The depression status were evaluated using the Geriatric Depression Scale（ GDS）. All patients were divided into post-stroke depression group and non post-stroke depression group with a GDS score ≥5. CMB were divided into left hemisphere,right hemisphere,lobar,deep,and posterior fossa groups.The number of CMB in each location was recorded. The number of CMB in different location,the demographic data,clinical data and imaging data of the two groups were analyzed. Results Compared with the non-PSD group,PSD patients were more likely to have lobar CMB,the left hemisphere CMB,female,higher NIHSS score,severe WML lesions,deep LI and the left hemisphere LI. Lobar CMB remained an independent risk factor of PSD in the multivariate analysis,with an odds ratio of 5. 843（ P =0. 040）. Conclusion The results suggest lobar CMB and left hemisphere CMB are risk factors for PSD,other risk factors include female,severe neurological deficits,brain white matter lesions,deep LI and left hemisphere LI.

关 键 词：脑微出血 腔隙性脑梗死 卒中后抑郁 危险因素 

分 类 号：R743.3[医药卫生—神经病学与精神病学]