Acute Bilateral Optic Neuritis in Active Ankylosing Spondylitis  

作　　者：Shuo Zhao Quan-Gang Xu Jian Zhu Chun-Xia Peng Xiao-Ming Li Huan-Fen Zhou Shan-Shan Cao Shi-Hui Wei 

机构地区：[1]Department of Neuro-ophthalmology, The Chinese People's Liberation Army General Hospital, Beijing 100853, China [2]Department of Clinical Medicine, Medical School of Nankai University, Tianjin 300071, China [3]Department of Rheumatology, The Chinese People's Liberation Army General Hospital, Beijing 100853, China

出　　处：《Chinese Medical Journal》2015年第20期2821-2822,共2页中华医学杂志（英文版）

摘　　要：Ankylosing spondylitis （AS）, which primarily affects the sacroiliac joints, spine, and enthuses, is a chronic inflammatory rheumatic disorder. Acute anterior uveitis is the most common ophthalmologic involvement, whereas optic neuritis （ON） rarely coexists with AS.r^j ON is an immune-mediated inflammation of the optic nerve, which could be the initiated symptom of multiple sclerosis （MS） or neuromyelitis optica （NMO）. Bilateral simultaneous ON with long enhanced optic nerve lesions in magnetic resonance imaging （MRI） was considered as features of NMO spectrum disorders （NMOSDs）. However, comprehensive review of the current literature showed little evidence of AS as an accompanied autoimmune condition in NMO,121 and the specific biomarker aquaporin-4 antibody （AQP4-Ab） was negative in our patient. In the current report, we present the first case of ON with active AS in a Chinese male patient. The association between the two diseases remains to be evaluated.Ankylosing spondylitis （AS）, which primarily affects the sacroiliac joints, spine, and enthuses, is a chronic inflammatory rheumatic disorder. Acute anterior uveitis is the most common ophthalmologic involvement, whereas optic neuritis （ON） rarely coexists with AS.r^j ON is an immune-mediated inflammation of the optic nerve, which could be the initiated symptom of multiple sclerosis （MS） or neuromyelitis optica （NMO）. Bilateral simultaneous ON with long enhanced optic nerve lesions in magnetic resonance imaging （MRI） was considered as features of NMO spectrum disorders （NMOSDs）. However, comprehensive review of the current literature showed little evidence of AS as an accompanied autoimmune condition in NMO,121 and the specific biomarker aquaporin-4 antibody （AQP4-Ab） was negative in our patient. In the current report, we present the first case of ON with active AS in a Chinese male patient. The association between the two diseases remains to be evaluated.

关 键 词：Ankylosing Spondylitis AQUAPORIN-4 Multiple Sclerosis Neuromyelitis Optica Optic Neuritis 

分 类 号：TP391.41[自动化与计算机技术—计算机应用技术] TH17[自动化与计算机技术—计算机科学与技术]