利培酮治疗难治性精神分裂症依从性3a随访比较  

Comparison of Compliance between Risperidone and Colzapine while Treating-Resistant Schizophrenia:a three year′s follow-up

作　　者：余国汉[1] 丁国安[1] 李? 朱英娥[1] 梁绮霞[1] 

机构地区：[1]广东省广州市脑科医院,510370

出　　处：《中国误诊学杂志》2002年第8期1143-1144,共2页Chinese Journal of Misdiagnostics

摘　　要：目的　比较利培酮与氯氮平对难治性精神分裂症疗效及依从性。方法　对原来在我院门诊及正在住院难治性精神分裂症 135例有效病例利培酮组 6 8例 ,氯氮平组 6 7例 ,分别用利培酮和氯氮平继续治疗 3a,在治疗前及治疗后 2、4、6、36个月用 BPRS、SANS、SDSS、CGI量表评定疗效。结果　在治疗难治性精神分裂症 3a随访利培酮 6 4例坚持用药 ,有效 6 1例 ,脱落 4例。氯氮平 44例坚持用药 ,有效 42例 ,脱落 2 3例。治疗有效病例的 3 a用药依从性随访比较有显著性差异 (P<0 .0 5 )。结论　利培酮治疗难治性精神分裂症以椎体外系不良反应为主 ,依从性高 ,疗效显著。Objective To compare effectiveness and compliance of risperidone and clozapine while treating resistant schizophrenia.Methods 135 cases of resistant schizophrenic outpatients or inpatients were collected,among which 68 cases were sensitive to risperidone treatment(n=68) and 67 to clozapine treatment (n=67).Effects of the two treatments were assessed before and during (2,4,6 and 36 months) using BPRS,SANS,SDSS and CGI.Results In the risperidove treated group,64 patients finished the trial,among which 61 were sensitive and 3 dropped.For the clozapineforty treated group,44 finished the trial ,among which 42 were sensitive and 23 dropped. Significant difference in the rate of effecliveness after there year's follow up between the two groups was found(P<0.05).Conclusions Risperidol for treatment resistant schizophrenia had high compliance,better effectiveness.Extrapyramidal symptoms (EPS) were risperidol′s main adverse effects.

关 键 词：利培酮 难治性精神分裂症 依从性 疗效 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R971.4[医药卫生—临床医学]