丛生蛋白参与年龄相关性黄斑变性的作用机制  

Action mechanism of clusterin in age-related macular degeneration

作　　者：叶子[1] 李朝辉[1] 何守志[1] 

机构地区：[1]北京市解放军总医院眼科,北京市100853

出　　处：《眼科新进展》2015年第11期1087-1089,1093,共4页Recent Advances in Ophthalmology

基　　金：国家重点基础研究发展计划(编号:2011CB510200)~~

摘　　要：丛生蛋白是玻璃膜疣的主要蛋白成分之一。近年来研究发现丛生蛋白与衰老密切相关,不仅通过对补体系统的调节参与年龄相关性黄斑变性(age-related macular degeneration,AMD)炎症反应发生机制,也与氧化还原反应密切相关,是AMD发生过程中氧化应激反应的感受器。本文就丛生蛋白参与AMD作用机制的研究进展进行综述。Clusterin is one of the major component of drusen. In recent years, stud- ies have found that clusterin is related to ageing. It is not only involved in inflammation mechanism in age-related macular degeneration （AMD） through regulating the comple- ment system, but also related with the oxidation reduction reaction, acting as a sensor for oxidative stress. This article reviews the research progress of clusterin protein in AMD, so as to find a new target for future therapy of AMD.

关 键 词：年龄相关性黄斑变性 视网膜色素上皮细胞 丛生蛋白 

分 类 号：R774.5[医药卫生—眼科]