经单鼻孔蝶窦入路垂体腺瘤切除术后死亡原因分析并文献复习  

Analysis of the death causes after endonasal transsphenoidal pituitary adenoma resection and review of literatures

作　　者：李振举[1] 马金良[1] 张弘[1] 张维萍[2] 罗元平[2] 

机构地区：[1]吉林大学第四医院脑外科,长春130011 [2]吉林大学第四医院病理科,长春130011

出　　处：《中国微侵袭神经外科杂志》2015年第11期494-497,共4页Chinese Journal of Minimally Invasive Neurosurgery

摘　　要：目的探讨经单鼻孔蝶窦入路垂体腺瘤切除术后死亡原因。方法回顾性分析4例经单鼻孔蝶窦入路垂体腺瘤切除术后死亡病例的临床资料,经过系统的病理学解剖检查,标本用10%甲醛固定,采用苏木精-伊红染色及光学显微镜观察并分析其死亡原因。结果 4例都存在蛛网膜下腔出血及脑水肿。出血部位主要分布在脑干腹侧面、小脑底部。其中1例第四脑室内可见血肿形成,1例合并肺动脉栓塞。结论蛛网膜下腔出血是经单鼻孔蝶窦入路垂体腺瘤切除术后的主要死亡原因之一,肺动脉栓塞是其较少见的死亡原因。Objective To analyze the causes of death after endonasal（ single nostril） transsphenoidal pituitary adenoma resection（ETPAR）. Methods Clinical data of 4 patients who died after ETPAR were analyzed retrospectively. The specimens were fixed by 10%formaldehyde solution after systemic pathological autopsy. Haematoxylin-eosin staining and light microscopy were performed to observe and analyze the causes of death. Results Subarachnoid hemorrhage and brain edema existed in all the patients. The hemorrhage distributed mainly in the ventral surface of the brain stem and the bottom of the cerebellum. Thrombus formation was seen in the fourth ventricle in 1 patient, and associated with pulmonary embolism in 1. Conclusion Subarachnoid hemorrhage is one of the main causes of death after ETPAR, while pulmonary embolism may be a rare cause of death.

关 键 词：垂体肿瘤 入路 经单鼻孔蝶窦 死亡原因 尸体解剖 

分 类 号：R736.4[医药卫生—肿瘤]