眼区阅读测验中文版在识别轻度认知障碍与阿尔茨海默病中的作用  

Effect of Chinese version of ＆quot;Reading the Mind in the Eyes＆quot; test on the diagnosis of mild cognitive impairment and Alzheimer＆#39;s dementia

作　　者：马洁[1] 郭起浩[2] 张云云[1] 何梦祺[1] 

机构地区：[1]上海中医药大学附属岳阳中西医结合医院神经内科卒中单元,200437 [2]复旦大学附属华山医院神经内科

出　　处：《中华老年医学杂志》2015年第11期1218-1222,共5页Chinese Journal of Geriatrics

摘　　要：目的 探索眼区阅读测验（RME）中文版的修订及在识别轻度认知障碍（MCI）与阿尔茨海默病中（AD）的作用. 方法 对96例MCI、55例AD患者和95例健康人进行RME及简易智能检查量表（MMSE）、听觉词语测验（AVLT）等神经心理测验,分析健康组RME各项目的完成率及三组RME总分和各项目分,比较RME总项目（RME-T）和RME简版（RME-S）的特征. 结果 健康组RME-T总分为（23.7±4.7）分,MCI组为（19.9±4.9）分,AD组为（19.9±7.5）分,健康组和MCI组、健康组和AD组差异有统计学意义（均P＜0.01）.将健康组完成率＜50％,且在健康组、MCI组和AD组的比较中均无差异的项目剔除后,组成RME-S,共20项,进一步比较RME-T和RME-S,RME-T总分与3个项目无相关性（P＞0.05）,而RME-S总分与所有项目的得分均有显著相关性（P＜0.01）.RME-T和RME-S总分均与常规神经心理测验得分有显著相关性（P＜0.01）.分别以健康组和MCI组、健康组和AD组为对象,对RME-T、RME-S进行受试者工作特征曲线（ROC）曲线分析,发现在健康组和AD组中,曲线下面积（AUC） （RME-S）＞AUC（RME-T）（P＜0.01）,而在健康组和MCI组中,AUC（RME-S）＜AUC（RME-T） （P＞0.05）. 结论 RME效度良好,RME-S比RME-T内部一致性更佳,适用于中国人群,特别是MCI患者与AD患者,值得进一步推广应用.Objective To investigate the effect of the revision of Chinese Versions of ＂Reading the Mind in the Eyes＂Test（RME） on the diagnosis of mild cognitive impairment （MCI） and mild Alzheimer＇s dementia （AD）.Methods We compared performance on the cognitive test battery between 96 patients with MCI and 55 patients with AD and 95 control individuals.Neuropsychological tests, encompassing RME-T, Mini Mental State Examination （MMSE） and Auditory Verbal Learning Test （AVLT）, were conducted on 96 patients with MCI, 55 patients with AD and 95 healthy control individuals.Completion rate of RME-T in the normal group and the total scores and each item score of RME-T were analyzed, and the feature between RME-T and RME-S （RME-short） was compared.Results The total score of RME-T was （23.7±4.7） in normal group, （19.9 ± 4.9） in MCI group,and （19.9±7.5） in AD group.There were significant differences in the total score of RME-T among the three groups （t=13.9, P〈0.01）.The differences in the total score of RME-T between normal group and AD group, between normal group and MCI group were also significant （both P〈0.01）.RME-S was composed of 20 items after rejecting 16 items of RME T whose project completion rate was lower than 50% in the normal group and in which there was no significant difference among normal, MCI and AD groups.The correlations between the total score of RME-T and 3 item scores of RME-T were not significant （P〉0.05）.However, the total score of RME-S was highly correlated with each item score of RME-S （P〈0.01）.The total score of RME-T and RME S were highly correlated with each total score of the cognitive test battery （P〈0.01）.With the normal and MCI groups, normal and AD groups as the subjects, the receiver operating characteristic （ROC） curve analysis found that AUC（RME-S） was〉 AUC（RME-T） in normal and AD groups （P〈0.01）, whereas, AUC（RME-S） was〈AUC（RME-T） in normal and MCI groups （P〉0.05）.Conclusions RME has g

关 键 词：神经心理学测验 认知障碍 阿尔茨海默病 

分 类 号：R749.16[医药卫生—神经病学与精神病学]