Direct Three-Component Synthesis of a-Cyano Acrylates Involving Cascade Knoevenagel Reaction and Esterification  

作　　者：Yanfeng Jing Jiaojiao Meng Yunyun Liu Jie-Ping Wan 

机构地区：[1]Key Laboratory of Functional Small Organic Molecules, Ministry of Education, and College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang, Jiangxi 330022, China

出　　处：《Chinese Journal of Chemistry》2015年第10期1194-1198,共5页中国化学（英文版）

摘　　要：A direct three-component approach has been developed for the synthesis of a-cyano acrylates starting from al- dehydes, alcohols and a-cyano acetamide by employing cyanuric chloride as an organocatalyst. A class of structur- ally diverse a-cyano acrylates have been provided with good to excellent yields via the cascade transformation of Knoevenagel condensation and amide esterification.A direct three-component approach has been developed for the synthesis of a-cyano acrylates starting from al- dehydes, alcohols and a-cyano acetamide by employing cyanuric chloride as an organocatalyst. A class of structur- ally diverse a-cyano acrylates have been provided with good to excellent yields via the cascade transformation of Knoevenagel condensation and amide esterification.

关 键 词：three-component reaction ACRYLATES ORGANOCATALYSIS Knoevenagel reaction amide esterification 

分 类 号：O625.63[理学—有机化学] TQ433.436[理学—化学]