磁共振3D-ASL技术在预测胶质瘤术前分级中的应用  

The application of MR 3D-ASL in preoperative prediction of tumor grade in glioma patients

作　　者：田强[1] 张曦[1] 徐菲菲[1] 胡玉川[1] 颜林枫[1] 韩宇[1] 崔光彬[1] 

机构地区：[1]第四军医大学唐都医院放射科,陕西西安710038

出　　处：《实用放射学杂志》2015年第11期1758-1761,共4页Journal of Practical Radiology

摘　　要：目的 探讨三维动脉自旋标记（3D-ASL）技术在预测脑胶质瘤术前分级中的价值.方法 回顾性分析经术后组织病理和免疫组化证实的45例胶质瘤患者的3D-ASL结果,其中低级别胶质瘤组19例,高级别组26例.计算肿瘤血流灌注值（TBF）、正常白质区域血流灌注值（BFwM）及相对肿瘤血流量值（rTBF）（rTBF=TBF/BFwM）.采用独立样本t检验分析2组间各值的统计学差异,应用受试者工作特征曲线（ROC）分析TBF值与rTBF值预测胶质瘤术前分级的敏感性和特异度.结果 高级别组的TBF值与rTBF值均高于低级别组（P＜0.01）,BFWM值无显著差别（P＞0.05）.TBF值与rTBF值预测胶质瘤术前分级的敏感度和特异度均为92.3％和94.7％.结论 3D-ASL技术可以半定量测定胶质瘤灌注情况,对于预测胶质瘤术前分级具有重要价值.Objective To explore the value of 3D arterial spin labeling （3D-ASL） in predicting the preoperative grading of glio- mas. Methods Forty-five patients with gliomas confirmed by postoperative pathology and immunohistochemistry were collected ASL results and retrospective review was obtained parameters of tumor blood flow （TBF）, normal white-matter blood flow （BFwM）, and relative tumor blood flow （rTBF=TBF/BFwM） were calculated. Independent sample t test was performed for testing whether there were significant differences between groups of low-grade and high-grade gliomas. Receiver operating characteristic （ROC） analyses were conducted to determine the sensitivity and specificity for grading results. Results TBF and rTBF were higher in the high-grade glioma group than that in the low-grade glioma group （all P〈0.01}. The sensitivity and specificity for differentiating low-from high grade gliomas group were as follows：TBF 92. 3% and 94. 7%; rTBF 92. 3% and 94. 7% respectively. Conclusion The 3IYASL technique can be used to semi-quantitatively analyze the tumor blood flow perfusion, which demonstrates significant predictive value in differentiating the low-from high-grade gliomas preoperatively.

关 键 词：胶质瘤 分级 动脉自旋标记 磁共振成像 

分 类 号：R739.41[医药卫生—肿瘤] R445.2[医药卫生—临床医学]