老年肝脾γδT细胞淋巴瘤1例并文献复习  

A case of hepatosplenic γδ T cell lymphoma and literature review

作　　者：李蓉 包慎 冶秀鹏 智峰 宋丽君 王春华 

机构地区：[1]宁夏人民医院血液肿瘤科,银川750002

出　　处：《临床血液学杂志》2015年第6期990-992,共3页Journal of Clinical Hematology

摘　　要：肝脾γδ T细胞淋巴瘤（hepatosplenic γδ T cell lymphoma,HSγδTCL）是一种侵袭性结外淋巴瘤,肝脾发病,无淋巴结大,预后差,占所有外周T细胞淋巴瘤的5%以下,好发于年轻男性,中位发病年龄35岁左右〔1〕。老年HSγδTCL实为罕见,国内文献报道甚少。In order to explore the clinical pathologic characteristics and diagnosis of the hepatosplenic γδ Tcell lymphoma（HSγδTCL）,we analyzed the diagnosis and treatment of one case with HSγδTCL,and reviewed the relevant literature.The main performance of the patient was splenomegaly.The spleen pathological examination showed that lymphoma cells with phenotype CD3＋,CD4-,CD8-and CD5-invaded the red pulp.Tumor cells from bone marrow expressed CD3,CD56,TCRγδ,but did not express CD4,CD8,TCRαβby flow cytometry.TCRγδwas positive.The patient was diagnosed as HSγδTCL.HSγδTCL is a rare type of lymphoma and is always easily misdiagnosed.Its clinical manifestations lack of specificity,and the unique pathologic feature is important for diagnosis.Splenectomy is no longer required,and marrow biopsy combined with flow cytometry is sufficient for its diagnosis.

关 键 词：肝脾γδ T细胞淋巴瘤 流式细胞术 脾脏病理 骨髓活检 免疫组织化学 

分 类 号：R733.4[医药卫生—肿瘤]