长链非编码RNAs的生物功能及其与器官发育和恶性肿瘤的关系  

Long noncoding RNAs: biological functions and applications in organ development and malignant tumors

作　　者：张明娇[1] 吴勇[1] 李珉珉[1] 

机构地区：[1]暨南大学附属第一医院临床医学检验中心,广东广州510632

出　　处：《中国病理生理杂志》2015年第11期2107-2112,共6页Chinese Journal of Pathophysiology

基　　金：广东省医学科研基金资助项目(No.A2010327)

摘　　要：在组成人类的约30亿个碱基对中,蛋白编码序列只占1.5%,而其余不编码蛋白质的序列曾一度被认为是基因组进化过程中的＂垃圾序列＂。2013年发布的ENCODE研究数据表明,所谓的＂垃圾序列＂绝大多数被转录成分子长度超过200个核苷酸的长链非编码RNAs（long noncoding RNAs,lncRNAs）。Long noncoding RNAs（lncRNAs） are classified as transcripts 〉 200 nucleotides in length with lit- tle or no evidence of protein-coding potential, and can regulate gene expression at various levels, including transcriptional regulation, posttranscriptional processing and so on. It has been widely involved in cell differentiation, individual develop- ment and other important life processes. Recent studies show lncRNA-related dysfunction plays critical roles in various dis- eases, indicating that lncRNA may serve as a new target for disease diagnosis and treatment. This review summarizes the functions of lncRNAs, including various modes of lncRNAs in regulating gene expression, the roles of lncRNAs in differen- tiation and development, and the connection between lncRNAs and malignant tumor.

关 键 词：长链非编码RNAs 恶性肿瘤 

分 类 号：R730.23[医药卫生—肿瘤]