脱氢表雄酮衍生物对东莨菪碱所致小鼠记忆障碍的影响  

Dehydroepiandrosterone derivatives attenuates scopolamine-induced memory impairment in mice

作　　者：周斌[1] 张勤[4] 赵早瑞[2] 李文姬[3] 李绍顺 姜远英 殷明 

机构地区：[1]中国人民解放军第二军医大学药学院,药理学教研室,上海200433 [2]浙江省医学科学院,浙江杭州310013 [3]中国人民解放军第二军医大学,基础医学部,上海200433 [4]不详

出　　处：《解放军药学学报》2002年第4期193-195,共3页Pharmaceutical Journal of Chinese People's Liberation Army

基　　金：国家自然科学基金资助项目 No .3 9770 849

摘　　要：目的　研究脱氢表雄酮衍生物对小鼠记忆障碍的改善作用。方法　用东莨菪碱造成小鼠记忆障碍模型 ,用水迷宫法测定小鼠的学习记忆功能。结果　小鼠腹腔注射东莨菪碱 4mg·kg-1可造成明显的记忆障碍 ,给予脱氢表雄酮硫酸酯 (0 .1～5mg·kg-1,sc)对记忆有明显改善作用 ,给予脱氢表雄酮唾液酸苷 (0 .1～ 5mg·kg-1,sc)也有改善作用 ,在 1mg·kg-1剂量时能显著减少错误次数、缩短到达平台时间和游泳距离 (P <0 .0 5 )。结论　脱氢表雄酮唾液酸苷有记忆增强作用。Aim To investigate the antiamnesic effect of dehydroepiandrosterone derivatives on memory impairment in mice.Methods Pharmacological model of amnesia in mice was produced by scopolamine.Learning and memory was evaluated using mouse water maze.Results Significant memory deficit was made by scopolamine (4mg·kg -1 ,ip). Dehydroepiandrosterone sulfate (0.1～5mg·kg -1 ,sc) could improve the scopolamine-induced deficit.Dehydroepiandrosterone sialic glycoside (0.1～5mg·kg -1 ,sc) attenuated the deficit,decreased the time to find platform,errors of entering non-exit and swimming distance at the dosage of 1mg·kg -1 (P<0.05).Conclusion Dehydroepiandrosterone sialic glycoside had memory-enhancing effects.

关 键 词：神经甾体 脱氢表雄酮唾液酸苷 脱氢表雄酮硫酸酯 东莨菪碱 水迷宫法 记忆障碍 老年性痴呆 AD 

分 类 号：R749.16[医药卫生—神经病学与精神病学] R965[医药卫生—临床医学]