当归对高压氧暴露中的大鼠脑内氨基酸含量的影响  

Effect of Angelica sinensis on some free amino acids contents in rat brains exposed to hyperbaric oxygen

作　　者：李润平[1] 张汉明 陶恒沂 

机构地区：[1]中国人民解放军第二军医大学海医系航海医学教研室,上海200433 [2]中国人民解放军第二军医大学药学院生药学教研室,上海200433

出　　处：《解放军药学学报》2002年第4期212-214,共3页Pharmaceutical Journal of Chinese People's Liberation Army

基　　金：军队九五科研项目 No .96M0 75

摘　　要：目的　探讨当归是否通过影响氨基酸的含量而延缓氧惊厥的发生。方法　大鼠服用当归水煎液 2 0d后 ,在高压氧中暴露 2 0min ,然后测定脑内游离氨基酸含量。结果　经过高压氧暴露后 ,大鼠脑中游离氨基酸的含量都明显升高 ,P <0 .0 1;与对照组相比 ,当归可以使部分氨基酸 (天冬氨酸、苏氨酸、丝氨酸、谷氨酸、甘氨酸、丙氨酸 )含量保持在相对较低的水平 ,P<0 .0 1;有些甚至低于正常组 (苏氨酸、丝氨酸、谷氨酸 ) ,P <0 .0 1。结论　高压氧条件下当归能够逆转脑内氨基酸类神经递质的异常改变 ,这可能是它延缓氧惊厥发生的作用途径之一。Aim To study the possibility that Angelica sinensis could prevent oxygen convulsion,through changing the contents of amino acids in rat brain.Methods After taking water extracts of Angelica sinensis for 20 days,rats were exposed to hyperbaric oxygen (HBO) for 20minutes,then free amino acids contents in brain were analyzed with auto-analysis method.Results Almost all of amino acids levels increased significantly after exposed to HBO,while Angelica sinensis could keep some amino acids levels,including excitatory amino acids(EAA),at lower levels comparatively,even lower than that of the normal.Conclusions Under the condition of hyperbaric oxygen exposure,Angelica sinensis could reverse the abnormal changes of amino acids in rat brain,which may be one of the approaches through which Angelica sinensis could prevent hyperbaric oxygen convulsion.

关 键 词：高压氧 当归 氨基酸 氧惊厥 

分 类 号：R282.710.5[医药卫生—中药学]