小靶区调强放疗及化疗对鼻咽癌的远期疗效评价  

Long- term efficacy of small target region intensity- modulated radiotherapy and chemotherapy in treatment of patients with nasopharyngeal cancer

作　　者：赵一虹[1] 高军茂[1] 何合良[1] 

机构地区：[1]北京军区总医院放疗科,北京100700

出　　处：《实用临床医药杂志》2015年第21期73-76,共4页Journal of Clinical Medicine in Practice

摘　　要：目的探讨小靶区调强放疗及化疗治疗鼻咽癌的长期疗效。方法回顾性分析372例鼻咽癌患者的临床资料,所有患者均采取缩小临床靶区调强放疗及化疗,并对所有患者进行5年的随访。结果本组患者的5年总生存率、局部控制率、无区域复发生存率、无远处转移生存率及无局部淋巴结复发率分别为82.80%、95.16%、97.31%、86.02%及96.24%。多因素分析表明,年龄、T分期、N分期是制约生存的预后因素,T分期、N分期是无远处转移的预后因素。进展期鼻咽癌患者中,诱导化疗组的5年生存率高于无诱导化疗组(P>0.05),辅助化疗者5年无远处转移生存率明显低于无辅助化疗者(P<0.01)。结论小靶区调强放疗及化疗治疗鼻咽癌的效果好。Objective To explore the long- term efficacy of small target region intensity-modulated radiotherapy and chemotherapy in the treatment of patients with nasopharyngeal cancer.Methods Clinical materials of 372 patients with nasopharyngeal cancer were analyzed retrospectively,and all the patients were treated with intensity- modulated radiotherapy and chemotherapy and followed up for 5 years. Results The 5 years overall survival rate,local control rate,local- regeional- free rate,distant metastasis- free survival rate and local lymph node recurrence- free rate of the patients were 82. 80%,95. 16%,97. 31%,86. 02% and 96. 24% respectively. The multivariate analysis revealed that age,T staging and N staging were independent prognostic factors for overall survival rate,and T staging and N staging were independent prognostic factors for distant metastasis- free survival rate. The 5- year overall survival rate of patients with induction chemotherapy was higher than those without induction chemotherapy（ P〈 0. 05）. At the same time,the 5- year distant metastasis-free survival rate of patients with adjuvant chemotherapy was significantly lower than those without adjuvant chemotherapy（ P〈 0. 01）. Conclusion Intensity- modulated radiotherapy shows an ideal effect in the treatment of patients with nasopharyngeal cancer.

关 键 词：鼻咽癌 调强放疗 化疗 远期疗效 生存率 

分 类 号：R739.63[医药卫生—肿瘤]