阿托伐他汀联合甲钴铵对脑梗死患者同型半胱氨酸、血脂及神经功能的影响  

Impact of Atorvastatin Combined with Mecobalamin on Homocysteine, Blood Lipids and Neurological Function of Patients with Cerebral Infarction

作　　者：高焱[1] 贺亚龙[1] 马世红[1] 康静[1] 郭晓贤[1] 

机构地区：[1]陕西省延安市人民医院神经内科,716000

出　　处：《实用心脑肺血管病杂志》2015年第9期65-67,共3页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：陕西省科技厅资助项目(2011JE006)

摘　　要：目的探讨阿托伐他汀联合甲钴胺对脑梗死患者同型半胱氨酸(Hcy)、血脂及神经功能的影响。方法选择延安市人民医院2011年1月—2013年1月收治的脑梗死患者80例,按照随机数字表分为观察组和对照组,各40例。在常规治疗的基础上,对照组患者给予阿托伐他汀口服治疗,观察组患者在对照组基础上给予甲钴胺片口服治疗。比较两组患者治疗前及治疗后3 d、7 d和14 d血清Hcy水平和血脂指标〔包括总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL)及低密度脂蛋白(LDL)〕,并比较两组患者治疗前及治疗后14 d中国卒中量表(CSS)评分。结果治疗前和治疗后14 d两组患者血清Hcy水平比较,差异无统计学意义(P>0.05);治疗后3 d及7 d观察组患者血清Hcy水平低于对照组(P<0.05)。治疗前两组患者血清TC、TG、HDL及LDL水平比较,差异无统计学意义(P>0.05);治疗后3 d、7 d及14 d观察组患者血清TC、TG及LDL水平低于对照组,血清HDL水平高于对照组(P<0.05)。治疗前两组患者CSS评分比较,差异无统计学意义(P>0.05);治疗后14 d观察组患者CSS评分低于对照组(P<0.05)。结论阿托伐他汀联合甲钴胺可降低脑梗死患者血清Hcy水平,改善患者血脂及神经功能。Objective To investigate the impact of atorvastatin combined with mecobalamin on homocysteine,blood lipids and neurological function of patients with cerebral infarction. Methods A total of 80 patients with cerebral infarction were selected in the People＇s Hospital of Yan＇an from January 2011 to January 2013,and they were randomly divided into observation group and control group,each of 40 cases. Based on conventional treatment,patients of control group were given atorvastatin,while patients of observation group were given atorvastatin combined with mecobalamin. Serum homocysteine level and blood lipids index（ including TC,TG,HDL and LDL） before treatment and after 3 days,7 days and 14 days of treatment were compared between the two groups,Chinese Stroke Scale（ CCS） score before treatment and after 14 days of treatment were also compared.Results No statistically significant differences of serum homocysteine level was found between the two groups before treatment or after 14 days of treatment（ P〉0. 05）,while serum homocysteine level of observation group was statistically significantly lower than that of control group after 3 day,7 days of treatment,respectively（ P〈0. 05）. No statistically significant differences of serum level of TC,TG,HDL or LDL was found between the two groups before treatment（ P〉0. 05）; after 3 days,7 days and14 days of treatment,serum levels of TC,TG and LDL of observation group were statistically significantly lower than those of control group,while serum HDL level of observation group was statistically significantly higher than that of control group,respectively（ P〈0. 05）. No statistically significant differences of CCS score was found between the two groups before treatment（ P〉0. 05）,while CCS score of observation group was statistically significantly lower than that of control group after 14 days of treatment（ P〈0. 05）. Conclusion Atorvastatin combined with mecobalamin can effectively reduce the serum homocysteine level of patients with cereb

关 键 词：脑梗死 阿托伐他汀 甲钴胺 同型半胱氨酸 

分 类 号：R743.33[医药卫生—神经病学与精神病学]