乳腺癌调强放射治疗和常规切线野治疗的三维剂量学研究  

Three dimensional dosimetric study of radiation therapy and conventional tangential treatment of breast cancer

作　　者：祁峰[1] 

机构地区：[1]河南省商丘市第一人民医院放疗科,476100

出　　处：《中外女性健康研究》2015年第20期5-6,共2页Women＇s Health Research

摘　　要：目的：探究乳腺癌调强放射治疗和常规切线野治疗的三维剂量学差异。方法：选取2014年1月至2015年5月我院收治的7例乳腺癌患者，均行保乳手术后为其设计调强放射治疗和常规切线野治疗，并比较两种治疗方法在OARs与PTV上的三维剂量学差异。结果：两种放射治疗计划的靶区覆盖一致，95%靶体积接受50.0Gy的放疗剂量，99%的靶区体积接受95%的处方剂量；调强放射治疗与常规切线野治疗相比，V110%平均下降9.2%，差异具有统计学意义（P＜0.05）；3例左侧乳腺癌患者的心脏V30平均下降3.6%，差异具有统计学意义（P＜0.05）；同侧肺V20平均下降8.9%，同侧肺V30平均下降11.6%，组间差异均具有统计学意义（P＜0.05）。结论：调强放射治疗可以在保证靶区覆盖率的基础上，解决靶区剂量分布不均匀的问题，减少危及器官尤其是心脏、同侧肺的照射剂量和体积。Objective： To compare dosimetry of intensity-modulated radiation therapy and conventional tangential irradiation for breast cancer. Methods： 7 patients with breast cancer were chosen for study which were treated in our hospital between January 2014 and May 2015, a dosimetric comparison about OARs and PTV of intensity-modulated radiation therapy and conventional tangential irradiation was performed on each patient. Results： The PTV coverage in two plans were consistent, the dose of radiation that 95% PTV receieved was 50.0Gy, 99% PTV received 99% prescribed dose; compare to conventional tangential irradiation, V110% in intensity-modulated radiation therapy fell an average of 9.2 percent, V20 and V30 of ipsilateral lung fell an average of 3.6 percent and 8.9 percent respectively, the difference was statistically significant （P＆lt;0.05）. Conclusion： On the premise of the same PTV coverage, intensity-modulated radiation therapy has a better dose uniformity, and achieve a reduction of irradiation volume and dose at heart and ipsilateral lung.

关 键 词：乳腺癌 调强放射治疗 常规切线野治疗 

分 类 号：R730.55[医药卫生—肿瘤]