肿瘤相关因子在卵巢癌中的表达及其与淋巴结转移相关性研究  

Correlation between the expression of tumor-associated factor in ovarian cancer and metastatic lymph node

作　　者：林莉[1] 王金华[1] 

机构地区：[1]厦门市第二医院妇产科,福建厦门361000

出　　处：《中国临床药理学杂志》2015年第22期2211-2213,共3页The Chinese Journal of Clinical Pharmacology

基　　金：福建省教育厅基金资助项目(JA12145)

摘　　要：目的探讨癌抗原125、人附睾上皮分泌蛋白及糖类抗原199在卵巢癌中的表达及其与淋巴结转移的相关性。方法将103例上皮性卵巢癌患者分为试验组65例(发生淋巴结转移)和对照组38例(无淋巴结转移)。检测2组患者的血清癌抗原125、人附睾上皮分泌蛋白及糖类抗原199表达水平,并分析淋巴结转移与其相关性。根据贝叶斯定理分析血清癌抗原125、人附睾上皮分泌蛋白及糖类抗原199诊断淋巴结转移的敏感性、特异性及受试者工作特征曲线(ROC)下面积。结果对照组的血清癌抗原125、人附睾上皮分泌蛋白及糖类抗原199中位数分别为223.3 k U·L-1,82.0 pmol·L-1和10.9 U·m L-1;试验组分别为891.0 k U·L-1,238.0 pmol·L-1和16.3 U·m L-1,试验组的上述指标显著高于对照组(P<0.05)。癌抗原125判断淋巴结转移的敏感性为73.85%,特异性为73.68%,ROC曲线下面积为0.77;人附睾上皮分泌蛋白判断淋巴结转移的敏感性为80.00%,特异性为60.53%,ROC曲线下面积为0.69;糖类抗原199判断淋巴结转移的敏感性为64.62%,特异性为57.89%,ROC曲线下面积为0.65。结论癌抗原125、人附睾上皮分泌蛋白及糖类抗原199可作为卵巢癌淋巴结转移的血清标志物。Objective To evaluate the expression of serum cancer anti- gen 125 （CA125）, human epididymis protein 4 （HE4） and carbohy- drate antigen 199 （CA199） in ovarian cancer and their diagnostic values for lymph node metastasis. Methods One hundred and three cases of epithelial ovarian cancer patients were divided into treatment group （65 cases with lymph node metastasis） and control group （38 cases without lymph node metastasis）. The serum level of CA125, HE4 and CA199 were arrayed and compared between the treatment and control groups. And the diagnosis value of serum CA125, HE4 and CA199 were calculated by Bayes theorem. Results The median value of CA125, HE4 and CA199 were 891.0 kU ·L^-1, 238.0 pmol ·L^-1, 16.3 U·mL^-1 in the treatment group, significantly higher than those in control group, which were 223.3 kU ·L^-1,82.0 pmol ·L^-1, 10.9 U ·mL^-1, respectivley （ P 〈 0. 05 ）. The diagnosis sensitivity, specificity and AUC of lymph node metastasis were 73.85%, 73.68%, AUC =0. 77 for CA125, 80. 00% , 60. 53% , AUC =0.69 for HE4 and 64.62%, 57.89%, AUC =0. 65 for CA199. Conclusion The serum of CA125, HE4 and CA199 can be potential biomarker for diagnosis of lymph node metastasis of ovarian cancer.

关 键 词：卵巢癌 癌抗原125 人附睾上皮分泌蛋白 糖类抗原199 淋巴转移 

分 类 号：R737.31[医药卫生—肿瘤] R966[医药卫生—临床医学]