卵巢浆液性腺癌BRMS1、RIZ1和SATB1蛋白表达及其与预后的关系  

Expression and prognostic significance of BRMS1,RIZ1 and SATB1 in ovarian serous carcinoma

作　　者：张军[1] 马立[1] 李月红[2] 赵喜娃[1] 王恒树[2] 崔爱荣[2] 黄丽珍[1] 

机构地区：[1]河北医科大学第四医院妇科,石家庄050011 [2]河北医科大学第二医院病理科,石家庄050000

出　　处：《临床与实验病理学杂志》2015年第11期1214-1218,共5页Chinese Journal of Clinical and Experimental Pathology

基　　金：河北省自然科学基金(C2009001229)

摘　　要：目的探讨卵巢低、高级别浆液性腺癌中BRMS1、RIZ1和SATB1蛋白表达及其临床病理意义。方法应用免疫组化Eli Vision法检测卵巢低、高级别浆液性腺癌组织中BRMS1、RIZ1和SATB1蛋白的表达,对比分析三者在不同级别浆液性腺癌中的表达规律,并应用Kaplan-Meier单因素统计法分析三者与不同级别浆液性腺癌患者预后的关系。结果 BRMS1、RIZ1和SATB1蛋白在高级别组中的阳性率分别为43.9%、46.3%和51.2%;与对照组相比,BRMS1、RIZ1的表达明显降低,而SATB1明显升高(P<0.05)。低级别组中三者的阳性率分别为30.0%、35.0%和75.0%;交界性囊腺瘤中分别为55.6%、50.0%和55.6%;与对照组和囊腺瘤组比较,BRMS1、RIZ1的表达明显降低,而SATB1明显升高(P<0.05)。BRMS1、RIZ1和SATB1在低、高级别浆液性腺癌中的表达差异无显著性(P>0.05)。Kaplan-Meier单因素统计分析结果显示,高级别组BRMS1和RIZ1阳性患者3、5年生存率明显高于阴性患者,而SATB1阳性患者生存率明显低于阴性患者(P<0.05)。低级别组中二者未见明显差异(P>0.05)。结论 BRMS1和RIZ1表达降低,SATB1表达升高,它们既参与了高级别浆液性腺癌,也参与了低级别浆液性腺癌的发生,提示不同级别浆液性腺癌的发生仍然存在一些相同的分子改变。三者表达与高级别浆液性腺癌的预后有关,而与低级别浆液性腺癌无关。Purpose To investigate the difference of expression and prognostic significance of BRMSI, RIZ1 and SATB1 in low grade ovarian serous carcinoma （LGSC） and high grade ovarian serous carcinoma （HGSC）. Methods ]mmunohistochemical expression of BRMS1, RIZ1 and SATB1 was examined in cases with LGSC and HGSC. Kaplan-Meier analysis were used to assess the impact of BRMS1, RIZ1 and SATB1 expression on survival. Results BRMS1, RIZ1 and SATB1 expression were seen in 43.9% , 46. 3% and 51.2% HGSC cases. Compare to control, the expression level of BRMS1 and RIZ1 were significantly lower, but the expression level of SATB1 was significantly higher （P 〈 0. 05 ）. In LGSC, BRMS1, RIZ1 and SATB1 expression were seen in 30. 0% , 35.0% and 75.0% cases, meanwhile in 55.6% , 50. 0% and 55.6% borderline cystadenoma cases respectively. Compare to control and cystade- noma, the expression level of BRMS1 and RIZ1 were significantly lower, but the expression level of SATB1 was significantly higher （P 〈 0. 05 ）. There was no significant difference of BRMS1, RIZ1 and SATB1 expression between HGSC and LGSC （P 〉 0.05 ）. Kaplan- Meier analysis revealed that there were significantly improved overall survival （3 and 5 years） for patients with HGSC displaying high expression of BRMS1 and RIZ1, or low expression of SATB1 （P 〈 0. 05 ）, but no significantly improved overall survival for patients with LGSC （P 〉 0. 05）. Conclusions The low expression of BRMS1, RIZ1 and high expresion of SATB1 contribute to carcinogenesis of serous carcinoma including HGSC and LGSC, and were associated with a poor prognosis of HGSC, but not LGSC. It suggested that there are a few same molecule change for carcinogenesis of HGSC and LGSC.

关 键 词：卵巢肿瘤 浆液性腺癌 BRMS1 RIZ1 SATB1 预后 

分 类 号：R737.31[医药卫生—肿瘤]