星形细胞上调基因-1及Girdin在乳腺癌组织中的表达  

Expression of astrocyte elevated gene-1 and Girdin in breast carcinoma

作　　者：刘言[1] 李双齐[2] 刘景波[1] 

机构地区：[1]大庆市龙南医院(齐齐哈尔医学院第五附属医院)病理科,黑龙江163453 [2]大庆市龙南医院(齐齐哈尔医学院第五附属医院)普外科,黑龙江163453

出　　处：《中华实验外科杂志》2015年第11期2818-2819,共2页Chinese Journal of Experimental Surgery

摘　　要：目的 探讨星形细胞上调基因-1（AEG-1）和Girdin在乳腺癌组织中的表达及与乳腺癌临床病理特征的关系.方法 利用免疫组织化学Envision法检测88例乳腺癌组织及相应癌旁组织中AEG-1和Girdin的表达水平.结果 AEG-1在乳腺癌组织中表达率明显高于癌旁组织（85.23％比15.91％,P＜0.01）,AEG-1表达水平与乳腺癌肿瘤大小、TNM分期、淋巴结转移明显相关（P＜ 0.05）;Girdin在乳腺癌组织中表达率明显高于癌旁组织（52.27％比12.50％,P＜0.01）,Girdin表达水平与乳腺癌TNM分期、淋巴结转移明显相关（P＜0.05）.结论 检测乳腺癌中AEG-1和Girdin表达水平可有助于预测乳腺癌的生物学行为.Objective To investigate the expression of astrocyte elevated gene-1 （AEG-1） and Girdin in breast carcinoma and its correlation with the clinicopathologic features.Methods The expression of AEG-1 and Girdin was detected by immunohistochemical Envision technique in 88 cases of breast carcinoma tissues and paired non-cancerous adjacent breast tissues.Results The expression rate of AEG-1 in breast carcinoma tissues was higher than that in the paired non-cancerous adjacent breast tissues （85.23% vs.15.91%, P 〈0.01）.The expression of AEG-1 was related breast carcinoma to tumor size, TNM stage and lymph node metastasis （P 〈 0.05）.The expression rate of Girdin in breast carcinoma tissues was higher than that in paired non-cancerous adjacent breast tissues （52.27% vs.12.50%, P 〈 0.01）.The expression of Girdin was related breast carcinoma to TNM stage and lymph node metastasis （P 〈 0.05）.Conclusion The detection of AEG-1 and Girdin in the breast carcinoma may be helpful for predicting the biological behavior of the breast carcinoma.

关 键 词：星形细胞上调基因-1 Girdin 乳腺癌 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]