放射治疗原发性三叉神经痛的低剂量学研究  

A Study to treat the primary trigeminal neuralgia for low doses radiotherapy

作　　者：郭化东[1] 常金[2] 张艳英[2] 李爱菊[2] 张本华[2] 

机构地区：[1]南方医科大学附属江门医院,广东江门529000 [2]泰山医学院附属医院肿瘤放疗中心,山东泰安271000

出　　处：《泰山医学院学报》2015年第4期388-389,共2页Journal of Taishan Medical College

摘　　要：目的对原发性三叉神经痛作X-刀大口径准直器及低剂量放射治疗的临床研究。方法应用X-刀照射治疗原发性三叉神经痛患者95例,利用岩骨嵴三叉神经节压迹这一骨性标志选择靶点,10~13 mm口径准直器,中心剂量1 7 Gy推量至29 Gy,单次照射。结果在1~5个月缓解或消失,随着放疗剂量的加大,起效时间缩短,疼痛缓解效果较好;治愈37例,明显改善26例,有效18例,无效14例。5例病人在1个月内疼痛症状加重现象,2例分别于8,10个月后疼痛复发,经再次治疗后疼痛症状消失;全部病例均无并发症。结论岩骨嵴三叉神经节压迹这一骨性标志是原发性三叉神经痛放疗的可靠标志点,17Gy是大口径准直器X-刀治疗原发性三叉神经痛有效的剂量,29Gy的治疗效果更好。Objective： To study trigeminal neuralgia treated by X- ray knife using low dose and big diameter collimator. Methods： To treat 95 cases who have primary trigeminal neuralgia using X- ray knife,10 ~ 13 mm diameter collimator,17 Gy extend to 29 Gy doses in the center by single irradiation. to select target using the trigeminal impression on the crista of petrosal bone. Results： Pain belief had disappeared for 37 cases,diminished significantly for 26 cases and effectively for18 cases in 1 ~ 5 monthes,14 case were not effective. 5 cases aggravated in 1 month,2 cases had recurred after 8,10 monthes respectively and been treated again whose pains disappeared; all cases had no complications. Conclusions： The trigeminal impression on the crista of petrosal bone is a dependable symbol for the treatment. 17 GY is a effective dose for the treatment in large collimator and 29 Gy is better.

关 键 词：原发性三叉神经痛 X-刀 立体定向放射外科 低剂量放疗 

分 类 号：R745.11[医药卫生—神经病学与精神病学]