Effect of probucol on insulin resistance in patients with non-diabetic chronic kidney disease  

作　　者：Rui WANG Ri-Bao WEI Yue YANG Na WANG Meng-Jie HUANG Cui-Ming CAO Zi-Cheng WANG Guang-Yan CAI Xiang-Mei CHEN 

机构地区：[1]Department of Nephrology, Chinese PL,4 General Hospital, Beijing, China

出　　处：《Journal of Geriatric Cardiology》2015年第5期521-527,共7页老年心脏病学杂志（英文版）

摘　　要：Background Insulin resistance （IR） is present at all stages of chronic kidney disease （CKD） and is associated with CKD progression. Probueol can improve the prognosis of IR in diabetes mellitus （DM） patients. This study aimed to observe the effect of probucol on IR and kidney protection in non-diabetic CKD patients. Methods This was an open-label, non-placebo-controlled, randomized study. A total of 59 patients were randomized to the probucol group （0.5 g, twice daily） or the control group using a 1： 1 treatment ratio. IR was determined using a homeostatic model assessment-IR （HOMA-IR） index. An Excel database was established to analyze foUow-up data at weeks 0, 12, and 24. The primary outcome of interest was changes in the HOMA-IR, and the secondary outcomes of interest were changes in the estimated glomerular filtration rate （eGFR）, body mass index （BMI）, cholesterol, triglycerides, high-density lipoprotein （HDL）, low-density lipoprotein （LDL）, and 24-h urinary protein. Results The HOMA-IR index of the probucol group after 24 weeks was significantly decreased （P 〈 0.001） compared to the value before treatment （average decrease： 1.45; range： -2.90 to -0.43）. The HOMA-IR index in the control group increased （average increase： 0.54; range： -0.38 to 1.87）. For the secondary outcomes of interest, the changes between these two groups also exhibited significant differences in eGFR （P = 0.041）, cholesterol （P = 0.001）, fasting insulin （P 〈 0.001）, and fasting C-peptide （P = 0.001）. Conclusions Compared to angiotensin receptor blockers alone, the combination with probucol ameliorates IR in non-diabetic CKD patients and delays disease progression.

关 键 词：Chronic kidney disease Insulin resistance PROBUCOL 

分 类 号：S948[农业科学—水产养殖] Q578[农业科学—水产科学]