云南高校图书馆联盟文献共享服务平台- PROBUCOL

PROBUCOL: 作品数：30被引量：95H指数：6; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：潘其兴盛林欧大明刘革修刘亚军更多>>; 相关机构：山东医科大学附属医院平度市人民医院重庆医科大学附属第二医院天津市胸科医院更多>>; 相关期刊：《Acta Biochimica et Biophysica Sinica》《心血管病学进展》《Journal of Geriatric Cardiology》《心肺血管病杂志》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划山东省科技攻关计划山东省自然科学基金更多>>

The therapeutic potential of probucol and probucol analogues in neurodegenerative diseases: 《Translational Neurodegeneration》2024年第1期1023-1034,共12页Arazu Sharif John Mamo Virginie Lam Hani Al-Salami Armin Mooranian Gerald F.Watts Roger Clarnette Giuseppe Luna Ryu Takechi; supported by the National Health and Medical Research Council of Australia(GNT2001090);Medical Research Future Fund(MRF1201204),MSWA,McCusker Charitable Research Foundation and the Wen Giving Foundation.; Neurodegenerative disorders present complex pathologies characterized by various interconnected factors,including the aggregation of misfolded proteins,oxidative stress,neuroinflammation and compromised blood-brain ba...; 关键词：Neurodegenerative disease PROBUCOL Probucol analogues INFLAMMATION Blood-brain barrier Oxidative stress INFLAMMATION AMYLOID-BETA

Retraction note:Effect of probucol on autophagy and apoptosis in the penile tissue of streptozotocin-induced diabetic rats被引量：1: 《Asian Journal of Andrology》2022年第5期562-562,共1页Ke-Qin Zhang Tao Tian Liang-Liang Hu Hao-Ran Wang Qiang Fu; Retraction to:Asian Journal of Andrology 2020;20(4):409-13.Doi:10.4103/aja.aja_89_19.During our recent research,we found that some results showed contradiction to the results in our previous article mentioned above.We...; 关键词：FIGURE checked CONTRADICTION

Probucol decreases homocysteine-stimulated CRP production in rat aortic smooth muscle cells via regulating HO-1/NADPH oxidase/ROS/p38 pathway被引量：5: 《Acta Biochimica et Biophysica Sinica》2021年第2期212-219,共8页Yuxia Li Qun Zhao Yuan Cao Jigang Si Jing Li Kai Cao Xiaoming Pang; This work was supported by the grants from the National Natural Science Foundation of China(No.81600348);Shandong Provincial Natural Science Foundation,China(No.ZR2016HB25);Key R&D Program of Zibo(No.2019ZC010147).; The elevated homocysteine level is an independent risk factor for atherosclerosis, which is characterized as a chronic inflammatory disease associated with oxidative stress. We have confirmed that homocysteine can sti...; 关键词：ATHEROSCLEROSIS HOMOCYSTEINE PROBUCOL C-reactive protein inflammation

Effect of probucol on autophagy and apoptosis in the penile tissue of streptozotocin-induced diabetic rats被引量：3: 《Asian Journal of Andrology》2020年第4期409-413,共5页Ke-Qin Zhang Tao Tian Liang-Liang Hu Hao-Ran Wang Qiang Fu; the National Natural Science Foundation of China(No.81873830);the Shandong Provincial Medicine and Health Science Technology Development Plan(No.2016WS0423);the Shandong Provincial Natural Science Foundation(No.ZR2016HB32 and No.ZR2017BH036);the Shandong Provincial Key Research Program(No.2017GSF218071,No.2018GSF118083,and No.2018GSF118142).; Autophagy and apoptosis have been regarded as important processes in the development of diabetic erectile dysfunction(DMED).Probucol is considered to have anti-apoptotic effects,but its relationship with autophagy has...; 关键词：APOPTOSIS AUTOPHAGY erectile dysfunction PROBUCOL

Improved dissolution and oral absorption by co-grinding active drug probucol and ternary stabilizers mixtures with planetary beads-milling method被引量：5: 《Asian Journal of Pharmaceutical Sciences》2019年第6期649-657,共9页Fang Li Linsen Li Shaoning Wang Yan Yang Jia Li Dongchun Liu Sijie Zhang Siling Wang Hui Xu; financial support from the National Basic Research Program of China(973 Program,No.2009CB930300); The objective of this work is to construct a nanosuspension drug delivery system of probucol,a BCS II drug,in order to improve its dissolution and oral bioavailability.The wet milling procedure using planetary beads-m...; 关键词：PROBUCOL NANOSUSPENSION Ternary STABILIZERS systems PLANETARY beads-milling Bioavailability

Protective effects of probucol in rats with postoperative acute renal failure: 《Oncology and Translational Medicine》2018年第2期62-67,共6页Cheng Yang Jun Peng Xingfeng Ren; Supported by Scientific Research Project of Hubei Provincial Health and Family Planning Commission(No.WJ2015Z042); Objective We investigated the protective effect of probucol in rats with acute renal failure caused by various ischemia-reperfusion injuries(IRIs) after surgery.Methods Forty male Sprague-Dawley rats were randomly div...; 关键词：PROBUCOL ISCHEMIA-REPERFUSION acute renal failure oxidative stress

Influence of probucol-assisted retinal photocoagulation therapy on the visual performance and serum biochemical indexes in patients with early proliferative diabetic retinopathy: 《Journal of Hainan Medical University》2017年第23期140-144,共5页Xiao-Xia Wen De-Wen Tan Teng Fang Hong-Jun Li; Objective: To explore the influence of probucol-assisted retinal photocoagulation therapy on the visual performance and serum biochemical indexes in patients with early proliferative diabetic retinopathy. Methods: A t...; 关键词：EARLY PROLIFERATIVE DIABETIC RETINOPATHY PROBUCOL Retinal PHOTOCOAGULATION Visual performance

Effect of PAS triple therapy on nerve injury, oxidative stress and inflammatory response in patients with cerebral infarction: 《Journal of Hainan Medical University》2017年第20期118-121,共4页Li-Jun Deng; Objective: To study the effect of probucol + aspirin + atorvastatin (PAS) triple therapy on nerve injury, oxidative stress and inflammatory response in patients with cerebral infarction. Methods: Patients with acute c...; 关键词：Acute CEREBRAL INFARCTION PROBUCOL Oxidative stress RESPONSE Inflammatory RESPONSE

Probucol inhibits LPS-induced microglia activation and ameliorates brain ischemic injury in normal and hyperlipidemic mice被引量：17: 《Acta Pharmacologica Sinica》2016年第8期1031-1044,共14页Yeon Suk JUNG Jung Hwa PARK Hyunha KIM So Young KIM Ji Young HWANG Ki Whan HONG Sun Sik BAE Byung Tae CHOI Sae-Won LEE Hwa Kyoung SHIN; Aim： Increasing evidence suggests that probucol, a lipid-lowering agent with anti-oxidant activities, may be useful for the treatment of ischemic stroke with hyperlipidemia via reduction in cholesterol and neuroinfla...; 关键词：PROBUCOL LPS MICROGLIA ischemic stroke focal cerebral ischemia HYPERLIPIDEMIA inflammatory cytokines NEUROINFLAMMATION

Effect of probucol on insulin resistance in patients with non-diabetic chronic kidney disease被引量：2: 《Journal of Geriatric Cardiology》2015年第5期521-527,共7页Rui WANG Ri-Bao WEI Yue YANG Na WANG Meng-Jie HUANG Cui-Ming CAO Zi-Cheng WANG Guang-Yan CAI Xiang-Mei CHEN; Background Insulin resistance （IR） is present at all stages of chronic kidney disease （CKD） and is associated with CKD progression. Probueol can improve the prognosis of IR in diabetes mellitus （DM） patients. Th...; 关键词：Chronic kidney disease Insulin resistance PROBUCOL

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