Protective effects of probucol in rats with postoperative acute renal failure  

作　　者：Cheng Yang Jun Peng Xingfeng Ren 

机构地区：[1]Department of Nephrology, Wuhan General Hospital of PLA

出　　处：《Oncology and Translational Medicine》2018年第2期62-67,共6页肿瘤学与转化医学（英文版）

基　　金：Supported by Scientific Research Project of Hubei Provincial Health and Family Planning Commission(No.WJ2015Z042)

摘　　要：Objective We investigated the protective effect of probucol in rats with acute renal failure caused by various ischemia-reperfusion injuries(IRIs) after surgery.Methods Forty male Sprague-Dawley rats were randomly divided into a sham operation group(S group), ischemia reperfusion group(IR group), probucol low-dose treatment group(probucol + IR group 1, P+ IR1 group; probucol 250 mg/kg intragastric administration daily), and probucol high-dose treatment group(P + IR2 group; probucol 500 mg/kg intragastric administration daily). Rats in the S and IR groups were intragastrically administered with warm water every day. After 1 week, the kidney IRI rat models were prepared, after which the rats were fed for another week, and blood, urine, and the kidney tissue specimens were retained. A series of biochemical indices, superoxide dismutase(SOD), and malondialdehyde in the serum and kidney tissues were detected, and pathological changes in renal tissue were observed.Results Twenty-four-hour urinary protein excretion, urinary NAGase, Cys C, blood urea nitrogen(BUN), and creatinine were significantly lower in the P + IR1 and P + IR2 groups than in the IR group(P < 0.05). Superoxide dismutase in the serum and renal tissue increased significantly, malondialdehyde decreased significantly(P < 0.05), renal pathological injury was alleviated, and the kidney index improved significantly(P < 0.05).Conclusion Probucol can relieve various types of acute renal failure in postoperative rats.Objective We investigated the protective effect of probucol in rats with acute renal failure caused by various ischemia-reperfusion injuries（IRIs） after surgery.Methods Forty male Sprague-Dawley rats were randomly divided into a sham operation group（S group）, ischemia reperfusion group（IR group）, probucol low-dose treatment group（probucol ＋ IR group 1, P＋ IR1 group; probucol 250 mg/kg intragastric administration daily）, and probucol high-dose treatment group（P ＋ IR2 group; probucol 500 mg/kg intragastric administration daily）. Rats in the S and IR groups were intragastrically administered with warm water every day. After 1 week, the kidney IRI rat models were prepared, after which the rats were fed for another week, and blood, urine, and the kidney tissue specimens were retained. A series of biochemical indices, superoxide dismutase（SOD）, and malondialdehyde in the serum and kidney tissues were detected, and pathological changes in renal tissue were observed.Results Twenty-four-hour urinary protein excretion, urinary NAGase, Cys C, blood urea nitrogen（BUN）, and creatinine were significantly lower in the P ＋ IR1 and P ＋ IR2 groups than in the IR group（P 〈 0.05）. Superoxide dismutase in the serum and renal tissue increased significantly, malondialdehyde decreased significantly（P 〈 0.05）, renal pathological injury was alleviated, and the kidney index improved significantly（P 〈 0.05）.Conclusion Probucol can relieve various types of acute renal failure in postoperative rats.

关 键 词：PROBUCOL ISCHEMIA-REPERFUSION acute renal failure oxidative stress 

分 类 号：R692.5[医药卫生—泌尿科学]