The therapeutic potential of probucol and probucol analogues in neurodegenerative diseases  

作　　者：Arazu Sharif John Mamo Virginie Lam Hani Al-Salami Armin Mooranian Gerald F.Watts Roger Clarnette Giuseppe Luna Ryu Takechi 

机构地区：[1]Curtin Health Innovation Research Institute,Faculty of Health Sciences,Curtin University,Perth,WA,Australia [2]Perron Institute for Neurological and Translational Research,Perth,WA,Australia [3]School of Public Health,Faculty of Health Sciences,Curtin University,Perth,WA,Australia [4]School of Medicine,Faculty of Health and Medical Sciences,University of Western Australia,Perth,WA,Australia [5]Curtin Medical School,Faculty of Health Sciences,Curtin University,Perth,WA,Australia

出　　处：《Translational Neurodegeneration》2024年第1期1023-1034,共12页转化神经变性病(英文)

基　　金：supported by the National Health and Medical Research Council of Australia(GNT2001090);Medical Research Future Fund(MRF1201204),MSWA,McCusker Charitable Research Foundation and the Wen Giving Foundation.

摘　　要：Neurodegenerative disorders present complex pathologies characterized by various interconnected factors,including the aggregation of misfolded proteins,oxidative stress,neuroinflammation and compromised blood-brain barrier(BBB)integrity.Addressing such multifaceted pathways necessitates the development of multi-target therapeutic strategies.Emerging research indicates that probucol,a historic lipid-lowering medication,offers substantial potential in the realm of neurodegenerative disease prevention and treatment.Preclinical investigations have unveiled multifaceted cellular effects of probucol,showcasing its remarkable antioxidative and anti-inflammatory properties,its ability to fortify the BBB and its direct influence on neural preservation and adaptability.These diverse effects collectively translate into enhancements in both motor and cognitive functions.This review provides a comprehensive overview of recent findings highlighting the efficacy of probucol and probucol-related compounds in the context of various neurodegenerative conditions,including Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,and cognitive impairment associated with diabetes.

关 键 词：Neurodegenerative disease PROBUCOL Probucol analogues INFLAMMATION Blood-brain barrier Oxidative stress INFLAMMATION AMYLOID-BETA 

分 类 号：R74[医药卫生—神经病学与精神病学]