S-腺苷蛋氨酸治疗药物性胆汁淤积性肝病伴抑郁/焦虑患者的研究  

Research on S-adenosyl methionine in treating patients with drug induced cholestatic liver diseases associated with depression/anxiety

作　　者：张巍巍[1] 沈磊[2] 迟静[1] 耿长新[1] 许琳[1] 孙昕[1] 赵丽萍[1] 战淑慧[1] 

机构地区：[1]青岛市市立医院东院消化内科,山东青岛266071 [2]淄博市中心医院消化内二科,山东淄博255036

出　　处：《中国肝脏病杂志（电子版）》2015年第3期96-99,共4页Chinese Journal of Liver Diseases：Electronic Version

基　　金：青岛市科技发展计划项目(11-2-3-2-c81-nsh)

摘　　要：目的研究S-腺苷蛋氨酸对药物性胆汁淤积性肝病伴抑郁/焦虑患者的治疗作用。方法 38例不同病因的药物性胆汁淤积性肝病并抑郁/焦虑患者予S-腺苷蛋氨酸治疗,应用SDS/SAS量表分别评估、比较治疗前后各组患者抑郁/焦虑情况。结果 S-腺苷蛋氨酸治疗后,中草药致药物性肝病伴抑郁/焦虑患者以及抗生素、他汀类药物致药物性肝病伴抑郁患者胆汁淤积明显改善,抑郁/焦虑症状改善有显著差异(P值分别为0.001、0.011、0.018),而在抗肿瘤药物致药物性肝病患者中无显著性差异。结论 S-腺苷蛋氨酸在中草药以及抗生素、他汀类药物性胆汁淤积性肝病并抑郁/焦虑患者中具有保肝及抗抑郁的双重作用,这将为人类"生理-心理"疾病的全面治疗奠定基础。Objective To study the therapeutic effects of S-adenosyl methionine on patients with drug induced cholestatic liver disease associated with depression or anxiety. Methods Total of 38 patients with different causes of drug induced cholestatic liver diseases accompanying with depression or anxiety were selected and treated with intravenous use of S-adenosyl methionine 1.0 g for 2 weeks. Then, Zung＇s SDS/ SAS assessment were applied to compare the therapeutic effects of these groups. Results The symptoms of depression or anxiety in patients with Chinese traditional drug as well as antibiotics and statins drug induced liver cholestasis improved significantly after treatment with S-adenosyl methionine （P = 0.001, 0.011, 0.018, respectively）, however, there seemed no change in anti-neoplasm drugs induced liver cholestasis. Conclusions S-adenosyl methionine plays a dual role of liver protection and anti-depressants in patients with Chinese traditional drug as well as antibiotics and statins drug induced cholestatic liver disease associated with depression or anxiety, which will create a broad application in treating patients with ＂bio - psycho＂ diseases.

关 键 词：药物性肝病 胆汁淤积 焦虑 抑郁 S-腺苷蛋氨酸 

分 类 号：R575[医药卫生—消化系统]