急性脑梗死患者血清中肿瘤坏死因子-α和白细胞介素-18表达临床研究  

Clinical study of acute cerebral infarction patients on Serum tumor necrosis factor-a and interleukin-18 expression

作　　者：颜建辉[1,2] 刘剑萍[1] 黄丽娟[2] 

机构地区：[1]湖南省湘南学院临床系,湖南郴州423000 [2]湘南学院附属医院,湖南郴州423000

出　　处：《中华肿瘤防治杂志》2015年第B22期19-20,共2页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的观察急性脑梗死患者血清中肿瘤坏死因子（TNF）-α和白细胞介素（IL）-18浓度，探讨急性脑梗死的发病机制。方法检测86例急性脑梗死患者血清中TNF-α和IL-18浓度，并与对照组作比较。结果急性脑梗死患者血清中TNF—α和IL-18浓度高于对照组，P％0．01；急性脑梗死患者病情越重，血清中TNF-α和IL-18浓度越高，P％0．01，作相关分析均呈正相关（r值分别为0．596和0．612，P〈0．01。结论TNF—α和IL-18可能参与急性脑梗死患者炎症反应，对加剧脑梗死病情起重要作用；TNF-α和IL-18可能是预测脑梗死患者病情严重程度的重要生化指标。OBJECTIVE To observe expression 0f acute cerebral infarction patients on serum tumor necrosis factor （TNF）-α and interleukin （IL）-18, and explore lthe pathogenesis of acute cerebral infarction. METHODS Detected in 86 patients with acute cerebral infarction serum TNF-α and IL-18 concentrations, compared with the control group. RE- SULTS TNF-α and IL-18 concentrations on Serum of patients with acute cerebral infarction were higher than the control group （P〈0.01）. With acute cerebral infarction patients were more severe disease, and TNF-α and IL-18 concentrations were higher （P〈0.01）. correlation analysis were positive correlation （r=0. 596 or 0. 612, P〈0.01）. CONCLUSIONS TNF-α and IL-18 could involve in inflammatory response in patients with acute cerebral infarction, cerebral infarction of the aggravating conditions play an important role. TNF-a and IL-18 could predicte severity of cerebral infarction in patients with an important biochemical indicator.

关 键 词：脑梗死 肿瘤坏死因子Α 白细胞介素18 

分 类 号：R743[医药卫生—神经病学与精神病学]