人工关节置换联合新辅助化疗治疗四肢恶性骨肿瘤临床观察  

Effect of artificial joint replacement combined with neoadjuvant chemotherapy in treatment of malignant bone tumor of extremities

作　　者：赵学辉 张伟 阮腊林 舒勇[2] 

机构地区：[1]新余新钢中心医院,江西新余338001 [2]南昌大学第一附属医院,江西南昌330000

出　　处：《中华肿瘤防治杂志》2015年第B22期250-251,269,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的研究四肢恶性骨肿瘤采用人工关节置换和新辅助化疗联合方案的疗效。方法选取我院2011-01—2015-06收治的四肢恶性骨肿瘤患者46例为研究对象。随机分为两组各23例。对照组行人工关节置换术，试验组加用新辅助化疗方案，观察两组患者的治疗效果。结果两组并发症发生率为13．0％和21．7％，差异无统计学意义。试验组治疗有效19例（82．6％），高于对照组的12例（52．2％）；肢体功能优良率（78．3％）高于对照组（43．5％），两组比较差异均有统计学意义，P〈O．05。结论在四肢恶性骨肿瘤患者中，人工关节置换联合新辅助化疗效果确切，能够提高治疗有效率，促进肢体功能恢复，值得临床推广。OBJECTIVE To study the limb malignant bone tumors using artificial joint replacement and the curative effect of neoadjuvant chemotherapy combined solution. METHODS Our hospital of 46 patients with limb malignant bone tumors as the research object, were randomly divided into two groups, each group of 23 cases. One group of artificial joint replacement, another group of combined with neoadjuvant chemotherapy regimens, to observe the therapeutic effect of two groups of patients. RESULTS The incidence of complications in the two groups was 13.0 %, 21.7 %, no obvious difference. Group therapy effective 19 cases （82.6%）, higher than the control group of 12 cases （52.2%）. The rate of good limb function （78.3%） than the control group （43.5 %）. P〈0. 05, the difference was statistically significant. CON- CLUSIONS In patients with limb malignant bone tumors, artificial joint replacement in combination with neoadjuvant chemotherapy effect is exact. Can improve the treatment efficiency, promote the limb function recovery, worth clinical promotion.

关 键 词：恶性骨肿瘤 人工关节置换 新辅助化疗 治疗效果 

分 类 号：R738.1[医药卫生—肿瘤]