子宫内膜癌ras基因p21蛋白的表达及临床病理意义  

The Expression and Clinicopathologic Significance of ras Oncogene p21 Protein in Endometrial Carcinoma

作　　者：苏玲娣[1] 徐少婷[1] 滕晓东[1] 

机构地区：[1]南通医学院第二附属医院,江苏南通226001

出　　处：《河南肿瘤学杂志》2002年第4期256-257,共2页Henan Journal of Oncology

摘　　要：目的　研究ras基因p2 1蛋白在子宫内膜增殖症及子宫内膜癌的表达及临床病理意义。方法　应用免疫组化S -P法检测了66例子宫内膜癌及 2 0例子宫内膜增殖症组织中p2 1蛋白的表达。结果　子宫内膜癌p2 1蛋白阳性过表达率均为 5 3 0 3 % (3 5 /66) ,与子宫内膜增殖组有明显差异 ,其过表达与组织分级呈正相关 ,而与肿瘤浸润、转移无关。结论　p2 1蛋白过表达是子宫内膜癌分化差的重要指标 。Objective To study the expression of ras oncogene p21 protein in endometrial carcinoma and it′s clinicopathologic significance.Method Immunohistochemical method was used to examine the expression of p21 protein in 66 cases with endometrial carcinoma.Results The rate of overexpression of p21 protein was 53.03% (35/66),the overexpression of p21 protein was correlated with tumor poor differentiation and not correlated with tumor invasion and lympha node metastasis.Conclusion the overexpression of ras oncogene protein might be important markers in the degree of malignancy of endometrial carcinoma and helpful in the early diagnosis of endometrial carcinoma.

关 键 词：子宫内膜癌 ras基因蛋白 P21蛋白 免疫组织化学 基因表达 

分 类 号：R737.33[医药卫生—肿瘤]