0.5%马来酸右旋噻吗洛尔滴眼液的稳定性  

Study on the Stability of 0.5% Timolol Maleate Eye Drops

作　　者：吴飞华[1] 陈晓文[1] 梅文君[1] 

机构地区：[1]上海第二医科大学附属第九人民医院,上海市200011

出　　处：《中国药房》2002年第8期496-496,共1页China Pharmacy

摘　　要：目的 :研究马来酸右旋噻吗洛尔滴眼液的稳定性 ,并预测其室温贮存期。方法 :采用紫外分光光度法测定马来酸右旋噻吗洛尔滴眼液含量 ,以初匀速法预测其有效期。结果 :0 5 %马来酸右旋噻吗洛尔滴眼液在室温下 ,有效期仅70d ,而置于5℃冰箱中贮存 ,有效期可达1 2y。结论 :初匀速法预测药品有效期简便、省时、准确 ,适用于医院制剂稳定性研究。OBJECTIVE:To study the stability of timolol maleate eye drops and predict its storage period at room temperature METHODS:Timolol maleate was determined by UV-spectrophotometry,initial average rate method was used in predicting the expiry term RESULTS:Stability of the 0 5% timolol maleate eye drops was not so good,expiry term predicted at 25℃ was only 70 days,while at 5℃ was as long as 1 2 years CONCLUSIONS:Initial average rate method is rapid,convenient and precise,so it is suitable for stability study of hospital preparations

关 键 词：0.5%马来酸右旋噻吗洛尔滴眼液 初匀速法 稳定性 紫外分光光度法 

分 类 号：R927.11[医药卫生—药学]