氟哌噻吨美利曲辛辅助治疗肠易激综合征的Meta分析  

META- ANALYSIS OF EFFECT OF FLUPENTIXOL MELITRACEN AS ADJUNCTIVE THERAPY ON PATIENTS WITH IRRITABLE BOWEL SYNDROME

作　　者：陈键林[1] 张少华[1] 蚁璇[1] 

机构地区：[1]汕头市中心医院,广东汕头515031

出　　处：《现代医院》2015年第2期6-9,14,共5页Modern Hospitals

摘　　要：目的 系统评价氟哌噻吨美利曲辛片辅助治疗肠易激综合征的疗效.方法 通过检索CNKI中国知网数据库,检索有关比较氟哌噻吨美利曲辛片联合常规药物（治疗组）与常规药物（对照组）治疗肠易激综合征的随机对照试验（RCT）,采用Jadad量表对纳入文献进行质量评分,应用Revman5.0进行Meta分析.结果 共纳入20项随机对照试验,包括2 146例肠易激综合征患者.治疗组的总有效率明显高于对照组（RR =4.43,95％ CI：3.43 ～ 5.70,p ＜0.05）.亚组分析显示氟哌噻吨美利曲辛片联合马来酸曲美布汀、匹维溴铵的疗效均优于相应对照组（p＜0.05）.结论 在常规药物（匹维溴铵）基础上联用氟哌噻吨美利曲辛片可明显提高肠易激综合征的疗效.Objective To evaluate the therapeutic effect of flupentixol melitracen for irritable bowel syndrome. Methods China National Knowledge Infrastructure was retrieved to collect the randomized controlled trials （RCT） that compared the therapeutic effect of flupentixol melitracen plus conventional drug （treatment group） with conventional drug （control group）. The quality score of RCT was assessed with Jadad quality scale. Meta -analysis was performed with the RevMan 5.0 software. Results Twenty RCT involving 2146 IBS patients were enrolled. The total efficacy rate in treatment group was significantly higher than that in control group （RR = 4.43, 95 % CI： 3.43 - 5.70, p 〈 0.05 ）. Subcategory analysis showed that the therapeutic effect of flupentixol melitracen combined with maleate trimebutine and pinaverium was significantly superior to that of corresponding controls （p 〈0.05）. Conclusion Flupentixol melitracen combined with conventional drugs （ Pinaverium Bromide） can improve the therapeutic effect of IBS.

关 键 词：肠易激综合征 氟哌噻吨美利曲辛 META分析 

分 类 号：R574.62[医药卫生—消化系统]