高血压患者冲突监控加工异常与MMSE评分的相关性研究  

Relationship between MMSE and conflict monitoring in patients with hypertention

作　　者：刘茜[1] 司翠平[1] 周亚飞[2] 石晶[2] 闫中瑞[1] 

机构地区：[1]济宁市第一人民医院神经内科,山东272000 [2]济南大学山东省医学科学院医学与生命科学学院

出　　处：《脑与神经疾病杂志》2015年第6期445-448,共4页Journal of Brain and Nervous Diseases

基　　金：山东省科学发展计划(2008GG30002058)

摘　　要：目的 探讨高血压患者执行Go-Nogo任务时冲突监控机制的特点及与MMSE评分的相关性。方法 选取高血压患者、正常对照各15例为研究对象,采用MMSE量表及视觉事件相关电位Go-Nogo实验范式,记录行为学数据和32导脑电数据。结果 两组被试的Go刺激平均反应时、命中率无差异性,P〉0.05。Nogo-N2波幅[F（1,27）=3.081,P=0.038]、潜伏期[F（1,27）=2.582,P=0.047]组间比较,P〈0.05。Go-N2波幅、潜伏期组间比较,P〉0.05。高血压组MMSE评分显著低于正常对照（P〈0.05）,高血压组Nogo-N2潜伏期与MMSE分数呈负相关,相关系数为-0.293,P=0.036〈0.05。结论 高血压患者在200~300ms时间窗内冲突监控机制异常,Nogo-N2潜伏期与高血压患者MMSE评分相关,Nogo-N2可能对认知功能的诊断有潜在的价值,为高血压患者认知功能的进一步研究提供神经电生理依据。Objective To investigate the conflict monitoring mechanisms in patients with hypertension when performing Go /Nogo task and discussed the relationship between Go-N2, Nogo-N2 and the MMSE.Methods Selected 15 cases of hypertension patients and 15 cases of normal controls,using MMSE scale and visual event-related potentials Go-Nogo experimental paradigm, Behavior data and 32 channel EEG data were recorded.Results Behavior data of two groups were not significant difference（P〉0.05）, The results showed that ERP system： The amplitude （F（1,27）=3.081,P=0.038） and latency of Nogo-N2（F（1,27）=2.582,P=0.047） were significant difference between groups, P〈0.05.The amplitude and latency of Go-N2 were not significant difference（P〉0.05）. Hypertension group MMSE score was significantly lower than the control group（ P〈0.05） .The latency of Nogo-N2 were negatively correlated to the MMSE scores,r =-0.293,P=0.036〈0.05.Conclusion Hypertensive patients in the 200-300ms time window abnormal conflict monitoring mechanisms, Nogo-N2 latencies associated with MMSE score of hypertension patients, Nogo-N2 may have potential diagnostic value for cognitive function in patients with hypertension,provide neurophysiological basis for further study of cognitive function in patients with hypertension.

关 键 词：高血压 冲突监控 事件相关电位 简易精神状态量表 

分 类 号：R743.32[医药卫生—神经病学与精神病学]