Nucleostemin通过p53与非p53途径调控细胞增殖的研究进展  

Progress of Nucleostemin Regulated Cell Proliferation by p53/non-p53 Pathway

作　　者：王娇[1] 野娜 韩世愈[1] 

机构地区：[1]哈尔滨医科大学附属第四医院妇产科,哈尔滨150001

出　　处：《医学综述》2015年第22期4057-4059,共3页Medical Recapitulate

摘　　要：Nucleostemin(NS)是一种可在细胞核仁和核浆内穿梭的GTP结合蛋白,主要定位于核仁内,其在维持干细胞未分化状态、细胞周期进程、肿瘤细胞及干细胞的增殖与凋亡中发挥着重要作用。就NS调控细胞增殖的机制而言,目前仍存在争议。一部分研究认为,NS通过结合p53,发挥维持细胞增殖、抑制细胞凋亡的作用;另一部分研究则认为,NS通过细胞内其他通路及参与核糖体的生物合成,进而影响细胞的生物学功能。Nucleostemin（NS） is a GTP-binding protein, shuttling between nucleolus and nucleoplasm, and malnly located in the nucleolus. NS plays an important role in maintaining the undifferentiated state of stem cells, modulating cell cycle and proliferation and apoptosis of several cancer ceUs and stem cells. But the mechanism involved in regulation of cell proliferation of NS is currently still controversial. Some are convinced that NS promotes cell proliferation and inhibits cell apoptosis combined with p53, another part of the researchers consider non-p53 pathway is the regulatory factor for influencing the cellular functions.

关 键 词：p53途径 增殖 

分 类 号：R730.231[医药卫生—肿瘤]