慢性肾脏病与脑血管病关系的研究进展  

Chronic Kidney Disease and Cerebrovascular Disease

作　　者：郝茂林[1] 刘菲[1] 商笑[1] 杜怡峰[1] 

机构地区：[1]山东大学附属省立医院神经内科,济南250022

出　　处：《医学综述》2015年第22期4101-4104,共4页Medical Recapitulate

摘　　要：心脏疾病与脑血管病之间有很多共同的危险因素,一个脏器疾病的治疗及转归直接影响其他脏器疾病的治疗和预后,脑血管病与肾脏病之间的关系还没有引起大家的广泛关注,两者之间的关系类似于心脑血管病之间的关系。慢性肾脏病是指肾脏损害超过3个月、伴或不伴肾小球滤过率减低或者尿蛋白排泄作用增强。慢性肾脏病的患者更易发生脑卒中事件,越来越多的证据推测慢性肾脏病是脑血管的危险因子,同时与脑小血管病及认知障碍有密切关系。慢性肾脏病的患者脑卒中后神经功能损害更严重、转归更差;药物治疗也受到局限性。Heart disease and cerebrovascular disease have a lot of common risk factors ： the treatment and prognosis of one directly affect the treatment and prognosis of the other, however, the relationship between cerebrovascular disease and kidney disease has not caused extensive concern,which is similar to the relationship of the cardio-cerebrovascular diseases. Chronic kidney disease, defined as kidney damage for over 3 months, accompanied with/without reduced glomerular filtration rate or increased urinary albumin excretion. Increasing evidence suggests that it contributes to the risk and severity of cerebrovascular diseases. In particular, chronic kidney disease is also strongly associated with subclinical cerebrovascular abnormalities and cognitive impairment. Chronic kidney disease seems to be predictive of severe neurological deficits and poor vital and functional outcomes after both ischaemic and hemorrhagic strokes, which is partly due to the limitations of pharmacotherapies.

关 键 词：慢性肾脏病 脑血管病 治疗 

分 类 号：R743[医药卫生—神经病学与精神病学]