四氢原小檗碱类化合物两条全合成路线的探讨  

Discussion and Evaluation of Two Total Synthesis Route of Tetrahydroprotoberberines

作　　者：李昌[1] 王飞[1] 徐淑华[1] 宋文文[1] 葛海霞[1] 

机构地区：[1]湖州师范学院生命科学学院,浙江湖州313000

出　　处：《湖州师范学院学报》2015年第10期23-26,共4页Journal of Huzhou University

基　　金：2014-2015年湖州师范学院"大学生创新创业训练计划"学生科研项目;国家自然科学基金青年基金项目(21302052)

摘　　要：四氢原小檗碱类化合物(THPBs)具有多种生物活性,制备多种多样的THPBs衍生物对开发该类化合物具有重要意义.在文献调研基础上,对目前最常用的两条全合成路线的每一步反应特点以及各自优缺点进行了探索性的评价.结果表明,路线一更适合制备结构多样的THPBs衍生物.Tetrahydroprotoberberines （THPBs） have been demonstrated to possess various biological activities. The preparation of structurally diverse THPBs is very important for the development of this kind of compounds. In this paper, the characteristics of each step in the two most commonly used syn- thetic routes for preparing THPBs are analyzed based on literature research, the advantages and disad- vantages of these strategies are also discussed. The results show that route 1 was more suitable for the preparation of THPBs.

关 键 词：四氢原小檗碱类化合物 全合成 路线评价 

分 类 号：R914[医药卫生—药物化学]