Clonality: A New Marker for Gastric Cancer Survival  

作　　者：Fengju Song Kexin Chen Wei Zhang 

机构地区：[1]Department of Epidemiology and Biostatistics, Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, National Clinical Research Center of Cancer, Tianjin Medical University Cancer Institute and Hospital [2]Department of Pathology, The University of Texas MD Anderson Cancer Center

出　　处：《Journal of Genetics and Genomics》2015年第10期517-519,共3页遗传学报（英文版）

基　　金：funded by the program for Changjiang Scholars and Innovative Research Team in University in China (Grant No. IRT1076)

摘　　要：Continuous efforts have been made to identify molecular markers for the prognosis of gastric cancer, the second leading cause of cancer death accounting for 10% of cancer mortality worldwide （Ferlay et al., 2010; Chen et al., 2013）. Studies using candidate gene approach, GWAS （genome-wide asso- ciation study）, and expression profiling have reported markers significantly associated with gastric cancer survival （Luo et al., 2011; Kang et al., 2014; Song et al., 2014）, and these markers have contributed to the clinical prediction of patients＇ outcome. However, gastric cancer is a highly heterogeneous disease etiologically, clinically, and pathologically. In this sense, it is plausible that single markers like DNA sequence variation, or gene/microRNA expression cannot fully reflect the heterogeneous survival of gastric cancer.Continuous efforts have been made to identify molecular markers for the prognosis of gastric cancer, the second leading cause of cancer death accounting for 10% of cancer mortality worldwide （Ferlay et al., 2010; Chen et al., 2013）. Studies using candidate gene approach, GWAS （genome-wide asso- ciation study）, and expression profiling have reported markers significantly associated with gastric cancer survival （Luo et al., 2011; Kang et al., 2014; Song et al., 2014）, and these markers have contributed to the clinical prediction of patients＇ outcome. However, gastric cancer is a highly heterogeneous disease etiologically, clinically, and pathologically. In this sense, it is plausible that single markers like DNA sequence variation, or gene/microRNA expression cannot fully reflect the heterogeneous survival of gastric cancer.

关 键 词：A New Marker for Gastric Cancer Survival CLONALITY 

分 类 号：R735.2[医药卫生—肿瘤]