海狗油治疗非酒精性脂肪肝的研究  

Therapeutic effect of seal oil on non-alcoholic fatty liver disease

作　　者：胡中伟[1] 柯娥 黄春明[1] 郭家伟[1] 詹远京[1] 欧志涛[1] 

机构地区：[1]广州医科大学附属市第八人民医院内科,广东广州510440

出　　处：《广州医科大学学报》2015年第4期31-33,44,共4页Academic Journal of Guangzhou Medical University

基　　金：广东省科技计划项目(2010B031600008)

摘　　要：目的:评估海狗油ω-3多不饱和脂肪酸胶丸治疗非酒精性脂肪肝(NAFLD)的临床效果。方法:将2007年1月至2013年1月广州医科大学附属市第八人民医院收治的43例NAFLD患者随机分为试验组(26例)和对照组(17例),试验组服用海狗油ω-3多不饱和脂肪酸胶丸,对照组服用安慰剂,共24周。对比治疗前后病理分级、B超评分及丙氨酸基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、体质量指数(BMI)、甘油三酯(TG)、总胆固醇(TC)、胰岛素抵抗指数(HOMA-IR)等指标差异。结果:经24周治疗后,试验组B超评分、TG、BMI、HOMA-IR较治疗前明显降低(P<0.05),与对照组比较也明显较低(P<0.05)。两组肝脂肪变程度、炎症、纤维化、ALT、AST、TC比较,差异无统计学意义(P>0.05)。结论:海狗油ω-3多不饱和脂肪酸胶丸能降低NAFLD患者TG、BMI、HOMA-IR水平,改善脂肪肝B超分级,但与病理组织学改变的关系不明显。Objective： To assess the therapeutic effect of ω-3 polyunsaturated fatty acids（ PUFA） of seal oil on non-alcoholic fatty liver disease（ NAFLD）. Methods： Forty-three patients with NAFLD, who were hospitalized in Eighth Municipal People＇ s Hospital Affiliated to Guangzhou Medical University between January2007 and January 2013,were randomly divided into the study group（ n = 26） and control group（ n = 17）. The study group was given seal oil ω-3 PUFA soft capsule and the control group was given placebo for 24 weeks. The differences of pathological grade,ultrasound scores,alanine aminotransferase（ ALT）,aspartate transaminase（ AST）,body mass index（ BMI）,triglyceride（ TG）,total cholesterol（ TC）,insulin resistance（ HOMA-IR）index in two groups were compared before and after the treatment. Results： The ultrasound scores,TG,BMI and HOMA-IR were significantly decreased after 24-week treatment compared with those before the treatment in the study group（ P〈0. 05）,which were significantly decreased compared with those in the control group（ P〈0. 05）. There were no statistically significant differences in the fatty liver disease pathological change,inflammation,fibrosis,ALT,AST and TC between two groups（ P〈0. 05）. Conclusion： Seal oil ω-3 PUFA soft capsule can decrease TG,BMI and HOMA-IR levels,and improve fatty liver ultrasound grade in NAFLD patients,without significant correlation with the changes of pathologic histology.

关 键 词：非酒精性脂肪肝 Ω-3多不饱和脂肪酸 病理学 血脂 

分 类 号：R575.5[医药卫生—消化系统]