肠道菌群调控肠黏膜免疫及抗感染功能的研究进展  

Regulation of mucosal immunity and preventing infectious disease occurrence by intestinal microbiota

作　　者：袁建云 周燕红[3] 

机构地区：[1]湖北医药学院附属随州医院 [2]随州市中心医院季梁院区门诊内科,湖北省随州市441300 [3]湖北科技学院临床医学院,湖北省咸宁市437100

出　　处：《世界华人消化杂志》2015年第30期4852-4858,共7页World Chinese Journal of Digestology

基　　金：湖北省卫生计生委基金资助项目;No.WJ2015MB236~~

摘　　要：哺乳动物的肠道共生着数量庞大,结构复杂的菌群.菌群中的大部分细菌在长期的进化过程中与宿主形成一种共生关系.这些肠道菌群具有促进肠黏膜免疫系统发育和调控肠黏膜免疫抗感染的功能.本文主要从肠道菌群的定植、肠黏膜免疫组织或免疫细胞的功能调控以及肠道菌群直接或者通过调控免疫系统来对抗病原菌感染等方面进行综述.Trillions of bacteria are colonizing in the mammalian intestine,and most of these bacteria have co-evolved with the host in a symbiotic relationship.A principal function of the intestinal microbiota is to regulate the gut immune response and protect the intestine against pathogen infection.In this review,we provide an overview of the current understanding of the role of intestinal microbiota both in the development of intestinal lymphoid tissue and immune cells,and in directly or indirectly preventing the occurrence of infectious diseases.

关 键 词：微生物 淋巴发育 免疫细胞 抗病原菌感染 

分 类 号：R574[医药卫生—消化系统]