Pigmented well-differentiated hepatocellular neoplasm with β-catenin mutation  

作　　者：Lara Neves Souza Rodrigo Bronze de Martino Richard Thompson Sandra Strautnieks Nigel D Heaton Alberto Quaglia 

机构地区：[1]Institute of Liver Studies,King's College Hospital [2]Department of Gastroenterology,Discipline of Liver and Gastrointestinal Transplantation,Hospital das Clínicas,University of S?o Paulo

出　　处：《Hepatobiliary & Pancreatic Diseases International》2015年第6期660-664,共5页国际肝胆胰疾病杂志（英文版）

摘　　要：ABSTRACT： According to the most recent WHO classification of hepatocellular adenomas, a small percentage of inflammatory hepatocellular adenomas presents with mutation in the β-catenin gene and are at higher risk of malignant transformation. It has been recognized that adenoma-like hepatocellular neoplasms with focal atypia, or in unusual clinical context present with similar cytogenetic and immunohistochemistry characteristics to well-differentiated hepatocellular carcino- mas.ABSTRACT： According to the most recent WHO classification of hepatocellular adenomas, a small percentage of inflammatory hepatocellular adenomas presents with mutation in the β-catenin gene and are at higher risk of malignant transformation. It has been recognized that adenoma-like hepatocellular neoplasms with focal atypia, or in unusual clinical context present with similar cytogenetic and immunohistochemistry characteristics to well-differentiated hepatocellular carcino- mas.

关 键 词：hepatocellular adenoma hepatocellular carcinoma Β-CATENIN glutamine synthetase DIETHYLSTILBESTROL 

分 类 号：R735.7[医药卫生—肿瘤]