多电极同步射频消融与常规单电极重叠射频消融效果的实验观察  

Effect analysis of multi-electrode synchronous radiofrequency ablation and conventional single electrode overlapping ablation

作　　者：张艳阳[1] 顾仰葵[1] 黄金华[1] 高飞[1] 江雄鹰[2] 张天奇[1] 黄森渺 

机构地区：[1]中山大学附属肿瘤医院影像与微创介入中心华南肿瘤学国家重点实验室,广州510060 [2]中山大学孙逸仙纪念医院放射介入科

出　　处：《中华医学杂志》2015年第43期3537-3540,共4页National Medical Journal of China

基　　金：国家自然科学基金（81371652）;广东省计划项目（20128031800120）

摘　　要：目的 探讨转换控制器介导的cool-tip内冷循环多电极同步射频消融与常规单电极重叠消融在离体牛肝消融效果的差异.方法 采用电极裸露端长度为3、4 cm的多电极同步射频消融与常规单电极重叠射频消融离体牛肝,观察两种方法消融灶的形态特征,测量并比较消融灶大小差异.结果 两种方法形成的消融灶均呈椭球形.转换控制器介导的4 cm裸露端多电极同步射频消融16 min的消融灶纵径、横径、电极前端消融长度、体积分别为（7.12±0.52） cm、（5.71±0.47） cm、（1.77±0.29） cm、（102±20） cm3,均＞常规4 cin裸露端单电极重叠射频消融36 min的消融灶大小（均P＜0.01）.在相同的16 min消融时间内,转换器介导的4 cm裸露端电极产生的消融灶纵径和体积明显＞3 cm裸露端电极产生的消融灶（均P＜0.01）;但两者的横径和电极前端消融长度差异无统计学意义（均P＞0.05）.结论 与常规单电极重叠射频消融相比,转换控制器介导的多电极同步射频消融能在更短的时间内产生更大的消融范围,这可以为临床大肝癌消融治疗提供新的尝试.Objective To explore the different effects in ex vivo bovine liver between multiple cooltip internally cooled electrodes synchronous radiofrequency ablation via switching controller and conventional single electrode overlapping radiofrequency ablation.Method The above two methods were used to ablate in ex vivo bovine liver respectively.Electrode exposed end was 3 cm or 4 cm in length.The morphological characteristics of lesions created by two methods were observed, the sizes of the ablated lesions were measured and compared.Result The formation of lesions ablated by both two methods was ellipsoidal.The longitudinal diameter, transverse diameter, front-end diameter and volume of the lesions ablated 16 mins by multi-electrode synchronous radiofrequency ablation via switching controller were （7.12 ± 0.52） cm, （5.71 ±0.47） cm, （1.77 ±0.29） cm, （102 ±20） cm3 ,respectively.All of them are larger than the lesions ablated 36 mins by conventional single electrode overlapping radiofrequency ablation（P 〈 0.01）.At the same 16 mins, multi-electrode synchronous radiofrequency ablation via switching controller created longer longitudinal diameter and large volume（P 〈 0.01） with longer exposed end electrodes（4 cm vs 3 cm）.But the transverse diameter, the front-end diameter had no statistical difference （P 〉 0.05）.Conclusion Compared with the conventional single electrode overlapping radiofrequency ablation, multi-electrode synchronous radiofrequency ablation via switching controller create larger lesion in the shorter time.It may provide a new attempt for the clinical treatment of large hepatocellular carcinoma.

关 键 词：消融技术 肝肿瘤 多电极 转换控制器 

分 类 号：R735.7[医药卫生—肿瘤]