基于数据挖掘的中医治疗糖尿病处方用药规律分析  

Medication Rules for Treating Diabetes Based on Data Mining

作　　者：吴嘉瑞[1] 王凯欢 纪凯 张丹[1] 张晓朦[1] 杨冰[1] 俸润彬 

机构地区：[1]北京中医药大学,北京100102 [2]北京灸道堂中医研究院,北京100024

出　　处：《中国实验方剂学杂志》2015年第22期214-217,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81473547);北京市中医药科技发展基金项目(JJ-2010-70);北京中医药大学与北京灸道堂中医研究院合作项目(BUCM-JDT2014001);北京市与中央在京高校共建项目(BJGJ1420)

摘　　要：目的:探讨中医治疗糖尿病的用药规律。方法:广泛收集整理中医治疗糖尿病的处方,在构建处方数据库的基础上,采用关联规则算法和熵聚类方法,确定处方中各药物和药物组合的使用频次、药物间关联规则、核心药物组合等。结果:高频次药物包括黄芪、茯苓、地黄、山药、丹参等;高频次药物组合包括"丹参、黄芪","黄芪、地黄","茯苓、黄芪"等;置信度大于0.85的关联规则包括"山茱萸,牡丹皮,茯苓->山药","牡丹皮,泽泻,茯苓->山药","山药,牡丹皮,泽泻->茯苓"等。结论:中医治疗糖尿病多用益气养阴、补脾益肾、清热生津、活血化瘀之品,配伍精巧合法。Objective： To explore the medication rules of traditional Chinese medicine for treating diabetes. Method： The traditional Chinese medicine（ TCM） prescriptions for treating diabetes were collected to build a database based on TCM inheritance assist system. Association rules algorithm and entropy clustering methods were used to determine the frequency of single drug and drug combinations,the association rules between drugs,core drug combinations and so on. Result： Based on the analysis of prescriptions for treating diabetes,the frequently adopted drugs were Astragali Radix,Poria,Rehmanniae Radix,Dioscoreae Rhizoma,and Salviae Miltiorrhizae Radix et Rhizoma. The frequently adopted drug combinations were ‘Salviae Miltiorrhizae Radix et Rhizoma and Astragali Radix＇,‘Astragali Radix and Rehmanniae Radix＇,and‘Poria and Astragali Radix＇. In the association rules with a confidence of over 0. 85,the drug combinations included ‘Corni Fructus,Moutan Cortex,Poria- 〉Dioscoreae Rhizoma＇,‘Moutan Cortex,Alismatis Rhizoma,Poria-〉 Dioscoreae Rhizoma＇,and ‘Dioscoreae Rhizoma,Moutan Cortex,Alismatis Rhizoma-〉 Poria＇. Conclusion： In TCM,the drugs used for treating diabetes mostly have the effects of tonifying Qi and Yin,strengthening spleen and kidney,clearing heat and promoting fluid,and activating circulation to remove blood stasis,which reflects a refined and rational compatibility.

关 键 词：糖尿病 关联规则 聚类算法 

分 类 号：R287[医药卫生—中药学]