两种异穿心莲内酯-3-酮肟的合成及表征  

Synthesis of Isoandrographolide-3-Ketoxime

作　　者：彭瑾[1] 蒋章勇 彭梅 

机构地区：[1]第三军医大学新桥医院药学部,重庆400037 [2]贵州三仁堂药业有限公司,贵州遵义563003 [3]贵州省中科院天然产物化学重点实验室,贵州贵阳550002

出　　处：《精细化工中间体》2015年第5期38-41,共4页Fine Chemical Intermediates

摘　　要：以穿心莲内酯为起始原料,通过脱羟基、三苯甲烷保护、羟基氧化、脱保护、肟化等反应过程,合成了2个未见文献报道的异穿心莲内酯-3-酮肟类化合物,收率分别为54.3%和59.1%,其结构经~1H NMR、^(13)C NMR、ESI-MS以及元素分析进行表征。Two new analogues with ketoxime-substituted of isoandrographolide were synthesized by selective dehydroxylation, selective hydroxyl protection, oxidation, de -protection and oximation reactions using andrograpbolide as the starting material. The total yield were 54.3% and 59.1% respectively. The obtained analogues of isoandrographolide were characterized by 1H-NMR, 13C-NMR, ESI-MS and Elemental Analysis.

关 键 词：异穿心莲内酯 酮肟 异穿心莲内酯-3-酮肟 

分 类 号：R914.5[医药卫生—药物化学]