山东省皮肤恶性黑色素瘤患者的临床特征与预后危险因素分析(附61例报告)  

Clinical features and prognostic factors of cutaneous malignant melanoma in Shandong Province: report of 61 cases

作　　者：张敏[1] 穆晓楠[2] 马伟元[3] 党宁宁[1] 张楠[4] 

机构地区：[1]山东大学附属济南市中心医院皮肤科,山东济南250013 [2]山东大学附属济南市中心医院保健科,山东济南250013 [3]山东大学齐鲁医院皮肤科,山东济南250012 [4]山东大学附属济南市中心医院肿瘤科,山东济南250013

出　　处：《山东大学学报（医学版）》2015年第11期80-84,共5页Journal of Shandong University:Health Sciences

摘　　要：目的分析山东省皮肤恶性黑色素瘤(CMM)患者的临床特征,并探讨其临床病理特征与预后的相关危险因素。方法对2009年1月至2014年12月收治的CMM患者61例的临床特点与预后进行记录与随访,采用SPSS1 13.0软件,Kaplan-M eier法计算生存率,Log-rank法比较各组的生存率,Cox模型进行多因素分析。结果61例患者1、3、5年生存率分别为82.0%、23.0%、16.4%。患者的5年生存率与临床分期、病变部位有无溃疡及是否接受手术切除有相关性(P均<0.01)。Cox多因素分析显示,临床分期是CMM患者5年生存率的独立危险因素。结论临床分期是山东省CMM患者不良预后的独立危险因素。Objective To investigate the clinical features and prognostic factors of cutaneous malignant melanoma （CMM） in Shandong Province. Methods Clinical data of 61 CMM cases treated during Jan. 2009 and Dec. 2014 were retrospectively reviewed. The survival rates were calculated with Kaplan-Meier method and compared with log- rank test. The independent prognostic factors were evaluated with Cox regression multivariate analysis. Results The 1 -year, 3-year and 5-year survival rates of the 61 patients were 82.0%, 23.0%, and 16.4%, respectively. The 5-year survival rate was significantly associated with clinical staging （ P 〈 0.01 ）, ulceration （ P 〈 0.01 ）, and operation （ P 〈 0.01 ）. Clinical staging was the independent prognostic factor. Conclusion Clinical staging is the independent risk factor for poor survival rate in patients with CMM in Shandong Province.

关 键 词：皮肤恶性黑色素瘤 预后 生存分析 山东省 

分 类 号：R739.5[医药卫生—肿瘤]