N-myc downstream-regulated gene 2 in the nervous system： from expression pattern to function  

作　　者：Kaifeng Lin Anqi Yin Libo Yao Yan Li 

机构地区：[1]Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an 710032, China [2]Department of Anesthesiology, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China

出　　处：《Acta Biochimica et Biophysica Sinica》2015年第10期761-766,共6页生物化学与生物物理学报（英文版）

基　　金：This work was supported by the grants from the National Natural Science Foundation of China （Nos. 81100764 and 81471110）.

摘　　要：Human N-myc downstream-regulated gene 2 （NDRG2） has been shown to be a multifunctional protein associated with cell proliferation, differentiation, transmembrane transport, and stress responses. In most mammalian brains, NDRG2 is principally expressed in astrocytic cells throughout different regions. NDRG2 has been increasingly implicated in the regulation of neurogenesis and in the development of nervous system diseases, including neurodegeneration, ischemia, and glioblastoma. This review summarizes the distribution and subcellular localization of NDRG2 in brain tissues, highlights the physiological actions of NDRG2 in the nervous system, and further discusses the roles of NDRG2 during the occurrence and development of several nervous system diseases.Human N-myc downstream-regulated gene 2 （NDRG2） has been shown to be a multifunctional protein associated with cell proliferation, differentiation, transmembrane transport, and stress responses. In most mammalian brains, NDRG2 is principally expressed in astrocytic cells throughout different regions. NDRG2 has been increasingly implicated in the regulation of neurogenesis and in the development of nervous system diseases, including neurodegeneration, ischemia, and glioblastoma. This review summarizes the distribution and subcellular localization of NDRG2 in brain tissues, highlights the physiological actions of NDRG2 in the nervous system, and further discusses the roles of NDRG2 during the occurrence and development of several nervous system diseases.

关 键 词：NDRG2 BRAIN ASTROCYTES cell stress nervous system diseases 

分 类 号：Q593.2[生物学—生物化学] Q274