支气管扩张患者血清基质金属蛋白酶组织抑制因子1水平及意义  

Level and significance of tissue inhibitor of matrix metalloproteinase 1 in serum in patients with bronchial dilation

作　　者：詹友勇[1] 石明[1] 王正艳[1] 杨中卫[1] 李威[1] 邝军[2] 

机构地区：[1]湖北医药学院附属东风医院呼吸内科,湖北省十堰市442000 [2]湖北医药学院附属人民医院呼吸内科

出　　处：《中国医药》2015年第12期1757-1759,共3页China Medicine

基　　金：湖北省教育厅科学技术研究项目（B2013112）

摘　　要：目的探讨支气管扩张患者血清基质金属蛋白酶组织抑制因子1（TIMP-1）水平及意义。方法选择2011年8月至2015年1月在湖北医药学院附属东风医院呼吸内科就诊的支气管扩张患者120例作为观察组，选择同期支气管无异常者120名作为对照组，检测2组肺功能、血清基质金属蛋白酶（MMP）、TIMP-1与炎症因子水平，并分析TIMP-1与各指标的相关性。结果观察组的第1秒用力呼气容积（FEV1）、FEV1／用力呼气容积（FVC）分别为（68±10）％和（70±6）％，而对照组分别为（98±13）％和（85±7）％，观察组的FEV1与FEV1／FVC值明显低于对照组（P〈0．05）。观察组血清MMP-2、MMP-9与TIMP—1均明显高于对照组，差异均有统计学意义[（62±11）ng／L比（26±11）ng／L、（134±25）ng／L比（45±13）ng／L、（44±9）ng／L比（20±9）ng／L，均P〈0．05]。观察组与对照组的血清IL-6分别为（41±5）ng／L与（13±4）ng／L，差异有统计学意义（P〈0．05）。Pearson相关性分析显示TIMP-1水平与MMP-2、MMP-9、IL-6水平呈明显正相关（r：0．563，r=0．505，r=0．509，均P〈0．05），与FEV1、FEV1／FVC值呈明显负相关（r=-0．438，r=-0．225，均P〈0．05）。结论支气管扩张患者血清TIMP-1与MMP的水平异常增高，与炎性反应及肺功能受限有关，TIMP-1水平检测可辅助判定支气管扩张的病情。Objective To investigate the level and significance of tissue inhibitor of matrix metalloproteinase 1 （TIMP-1） in serum in patients with bronchial dilation. Methods Totally 120 patients with bronchiectasis （observation group） and 120 subjected with normal bronchial from August 2011 to January 2015 were enrolled. The pulmonary function, the levels of matrix metalloproteinases （MMPs）, matrix metalloproteinase inhibitor （TIMP-1） and iutedeukin （IL）-6 in serum were assessed; the correlations of TIMP-1 with MMPs and IL-6 were analyzed. Results The forced expiratory volume in one second （ FEV1 ） and ratio of FEV1 and forced vital capacity in percentage （FEVj/FVC%） in observation group were significantly lower than those in control group [（68_10）% vs （98±13）%, （70±6）% vs （85±7）%] （P〈0.05）. The levels of serum MMP-2, MMP-9 and TIMP-1 in observation group were significantly higher compared with those in control group [（62±11） ng/Lvs （26±11） ng/L, （134±25） ng/Lvs （45±13） ng/L, （44±9） ng/L vs （20±9） ng/L] （P 〈0. 05）. The level of serum IL-6 in observation group was significantly higher than that in control group [ （41 ±5） ng/L vs （ 13 ± 4） ng/L] （ P 〈 0. 05 ）. Pearson correlation analysis showed that the expression of TIMP-1 was positively correlated with MMP-2, MMP-9 and IL-6 （r = 0. 563, r = 0.505, r = 0.509,P〈0.05）, was negatively correlated with FEV1 and FEVJFVC% （r= -0.438, r= -0.225, P〈0.05）. Conclusion The TIMP-1 and MMPs are abnormally increased in patients with bronchiectasis, which is related with inflammatory reaction and limited lung function; measure of TIMP-1 is helpful to determine the bronehiectasis condition.

关 键 词：支气管扩张 基质金属蛋白酶抑制剂 炎性反应 相关性 

分 类 号：R735.2[医药卫生—肿瘤]